1610430-63-1

Basic information

• Product Name: C₂₁H₂₁BrN₂O₃S
• CAS NO: 1610430-63-1
• Molecular Weight: 461.379
• Mol File: 1610430-63-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₁BrN₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₁BrN₂O₃S(1610430-63-1)
• EPA Substance Registry System: C₂₁H₂₁BrN₂O₃S(1610430-63-1)

Safety Data

• Hazardous Substances Data: 1610430-63-1(Hazardous Substances Data)

Upstream product

• 263390-69-8 3-(3-methoxymethoxypyridin-4-yl)-propenoic acid ethyl ester 
• 81245-25-2 3-(methoxymethoxy)pyridine 
• 6320-01-0 3-Bromothiophenol 
• 263390-70-1 3-(3-methoxymethoxypyridin-4-yl)-propionic acid ethyl ester 
• 263390-44-9 2-(3-bromophenylthio)pyridine-3-ol 
• 263390-84-7 3-(3-methoxymethoxypyridin-4-yl)-1-propanol 
• 6602-32-0 2-bromo-pyridin-3-ol 

Downstream Products

• 263391-11-3 2-(3-bromophenylthio)-3-[3-(3-hydroxypyridin-4-yl)propoxy]pyridine 

Relevant articles and documents

Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors

A series of 2,3-disubstituted pyridines were synthesized as potential non-emetic PDE4 inhibitors. To decrease brain exposure and minimize emesis, we modified the lipophilic moiety of a series of emetic PDE4 inhibitors and found that introduction of a hydroxy group into the pyridine moiety of the side chain led to non-emetic compounds with preserved PDE4 inhibitory activity. Following optimization at the phenoxy group, we identified compound 1 as a potent non-emetic PDE4 inhibitor. Compound 1 showed significant efficacy in an animal model of asthma without inducing emesis.