263391-11-3

Basic information

• Product Name: 2-(3-bromophenylthio)-3-[3-(3-hydroxypyridin-4-yl)propoxy]pyridine
• Synonyms: 2-(3-bromophenylthio)-3-[3-(3-hydroxypyridin-4-yl)propoxy]pyridine
• CAS NO: 263391-11-3
• Molecular Weight: 417.326
• Mol File: 263391-11-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3-bromophenylthio)-3-[3-(3-hydroxypyridin-4-yl)propoxy]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromophenylthio)-3-[3-(3-hydroxypyridin-4-yl)propoxy]pyridine(263391-11-3)
• EPA Substance Registry System: 2-(3-bromophenylthio)-3-[3-(3-hydroxypyridin-4-yl)propoxy]pyridine(263391-11-3)

Safety Data

• Hazardous Substances Data: 263391-11-3(Hazardous Substances Data)

Upstream product

• 1610430-63-1 C₂₁H₂₁BrN₂O₃S 
• 263390-69-8 3-(3-methoxymethoxypyridin-4-yl)-propenoic acid ethyl ester 
• 81245-25-2 3-(methoxymethoxy)pyridine 
• 6320-01-0 3-Bromothiophenol 
• 263390-70-1 3-(3-methoxymethoxypyridin-4-yl)-propionic acid ethyl ester 
• 6602-32-0 2-bromo-pyridin-3-ol 
• 263390-44-9 2-(3-bromophenylthio)pyridine-3-ol 
• 263390-84-7 3-(3-methoxymethoxypyridin-4-yl)-1-propanol 

Relevant articles and documents

Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors

A series of 2,3-disubstituted pyridines were synthesized as potential non-emetic PDE4 inhibitors. To decrease brain exposure and minimize emesis, we modified the lipophilic moiety of a series of emetic PDE4 inhibitors and found that introduction of a hydroxy group into the pyridine moiety of the side chain led to non-emetic compounds with preserved PDE4 inhibitory activity. Following optimization at the phenoxy group, we identified compound 1 as a potent non-emetic PDE4 inhibitor. Compound 1 showed significant efficacy in an animal model of asthma without inducing emesis.