1610460-73-5

Basic information

• Product Name: 3-benzyl-5-chloro-1-methyl-3-phenylindolin-2-one
• CAS NO: 1610460-73-5
• Molecular Weight: 347.844
• Mol File: 1610460-73-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-benzyl-5-chloro-1-methyl-3-phenylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyl-5-chloro-1-methyl-3-phenylindolin-2-one(1610460-73-5)
• EPA Substance Registry System: 3-benzyl-5-chloro-1-methyl-3-phenylindolin-2-one(1610460-73-5)

Safety Data

• Hazardous Substances Data: 1610460-73-5(Hazardous Substances Data)

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 1022-13-5 5-chloro-2-(methylamino)benzophenone 

Relevant articles and documents

Silica gel-mediated hydroamination/semipinacol rearrangement of 2-alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-oxindoles from alkynes and 1-(2-aminophenyl) ketones

2-Alkylaminophenylprop-1-yn-3-ols, prepared from the lithium diisopropylamide (LDA)- mediated 1,2-addition of alkynes to 1-(2-aminophenyl) ketones, can be converted to 3,3-disubstituted 2-oxindoles by using silica gel in n-hexane/ ethyl acetate (20:1 v/v) as the reaction medium. The utility of the approach as a potential scale-up strategy for the synthesis of 2-oxindoles was exemplified by the large-scale synthesis of one adduct in excellent yield. The synthetic applicability of this chemistry was also demonstrated by the recycling of the silica gel up to 8 times with no apparent loss of activity being observed for the same example.