1610460-91-7

Basic information

• Product Name: 1-methyl-3-phenyl-3-(4-(trifluoromethyl)benzyl)indolin-2-one
• CAS NO: 1610460-91-7
• Molecular Weight: 381.397
• Mol File: 1610460-91-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-methyl-3-phenyl-3-(4-(trifluoromethyl)benzyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-3-phenyl-3-(4-(trifluoromethyl)benzyl)indolin-2-one(1610460-91-7)
• EPA Substance Registry System: 1-methyl-3-phenyl-3-(4-(trifluoromethyl)benzyl)indolin-2-one(1610460-91-7)

Safety Data

• Hazardous Substances Data: 1610460-91-7(Hazardous Substances Data)

Upstream product

• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 1859-76-3 2-(methylamino)benzophenone 

Relevant articles and documents

Silica gel-mediated hydroamination/semipinacol rearrangement of 2-alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-oxindoles from alkynes and 1-(2-aminophenyl) ketones

2-Alkylaminophenylprop-1-yn-3-ols, prepared from the lithium diisopropylamide (LDA)- mediated 1,2-addition of alkynes to 1-(2-aminophenyl) ketones, can be converted to 3,3-disubstituted 2-oxindoles by using silica gel in n-hexane/ ethyl acetate (20:1 v/v) as the reaction medium. The utility of the approach as a potential scale-up strategy for the synthesis of 2-oxindoles was exemplified by the large-scale synthesis of one adduct in excellent yield. The synthetic applicability of this chemistry was also demonstrated by the recycling of the silica gel up to 8 times with no apparent loss of activity being observed for the same example.