1610527-75-7

Upstream product

• 100-59-4 phenylmagnesium chloride 
• 1610527-66-6 C₃₄H₂₈O₅ 
• 1610527-74-6 (E)-tert-butyl 3-phenyl-3-((1S,2S,5S)-1,2,5-tribenzyl-4-oxo-3,6-dioxabicyclo[3.1.0]hexan-2-yl)acrylate 
• 1610527-73-5 (1S,4R,5S)-4-benzoyl-1,4,5-tribenzyl-3,6-dioxabicyclo[3.1.0]hexan-2-one 
• 1610527-72-4 (1S,4S,5S)-1,4,5-tribenzyl-4-(hydroxy(phenyl)methyl)-3,6-dioxabicyclo[3.1.0]hexan-2-one 

Downstream Products

• 1610527-76-8 5-epi-ophiodilactone A 

Relevant academic research and scientific papers

Total synthesis of (-)-ophiodilactone A and (-)-ophiodilactone B

The first asymmetric total synthesis of (-)-ophiodilactone A and (-)-ophiodilactone B, isolated from the ophiuroid (Ophiocoma scolopendrina), is reported. The key features of the synthesis include the highly stereocontrolled construction of the structurally congested γ-lactone/δ-lactone skeleton through an asymmetric epoxidation, diastereoselective iodolactonization, and intramolecular epoxide-opening with a carboxylic acid, and biomimetic radical cyclization of ophiodilactone A to ophiodilactone B. Bioinspired synthesis: The first total synthesis of the title compounds has been accomplished in a highly stereocontrolled manner. Key features of the synthesis include an asymmetric epoxidation, a diastereoselective iodolactonization, an intramolecular epoxide opening with a carboxylic acid, and a biomimetic radical cyclization of ophiodilactone A to ophiodilactone B. Copyright