161053-66-3

Upstream product

• 174225-01-5 1-(2-((2-methoxyethoxy)methoxy)phenyl)ethanone 
• 105-58-8 Diethyl carbonate 
• 81254-83-3 2-<(2-methoxyethoxy)methoxy>benzoic acid 
• 81254-82-2 methyl 2-[(2-methoxyethoxy)methoxy]benzoate 
• 119-36-8 methyl salicylate 

Downstream Products

• 1028302-49-9 4-Benzyloxy-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-butyric acid ethyl ester 
• 1026233-36-2 2-[2-(2-Methoxy-ethoxymethoxy)-benzoyl]-5-phenylsulfanyl-pentanoic acid ethyl ester 
• 1028256-11-2 2-[2-(2-Methoxy-ethoxymethoxy)-benzoyl]-5-(2-methoxy-phenoxy)-pentanoic acid ethyl ester 
• 1027238-84-1 5-(3-Chloro-phenoxy)-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-pentanoic acid ethyl ester 
• 1026741-66-1 2-[2-(2-Methoxy-ethoxymethoxy)-benzoyl]-4-phenoxy-butyric acid ethyl ester 
• 1026937-46-1 2-[2-(2-Methoxy-ethoxymethoxy)-benzoyl]-5-phenoxy-pentanoic acid ethyl ester 
• 1027207-54-0 5-(Benzyl-phenyl-amino)-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-pentanoic acid ethyl ester 
• 1025897-05-5 5-[(4-Fluoro-phenyl)-phenyl-amino]-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-pentanoic acid ethyl ester 
• 161053-91-4 ethyl 3-[3-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)propoxy]benzoate 
• 161053-95-8 3-[3-(3-Cyanophenoxy)propyl]-4-hydroxy-2H-1-benzopyran-2-one 

Relevant academic research and scientific papers

Synthesis and herbicidal evaluation of novel 3-[(α-hydroxy- substituted)benzylidene]pyrrolidine-2,4-diones

A series of 3-[(α-hydroxy-substituted) benzylidene]pyrrolidine-2,4- dione derivatives were synthesized as candidate herbicides by reacting different aroyl acetates with N-substituted glycine esters. The new compounds were identified by 1H NMR spectroscopy and elemental analyses. Their herbicidal activities were evaluated. Some compounds exhibited excellent herbicidal activities at a dose of 187.5 g/ha. A suitable electron-donating substituent at the 2- and/or 4-position of the phenyl ring was essential for high herbicidal activity, a result that has not been reported before. It was also found that the title compound's structure-activity relationships were different from those of other similar kinds of earlier compounds, a result that may depend on the enol structure difference.

A novel nonpeptide HIV-1 protease inhibitor: Elucidation of the binding mode and its application in the design of related analogs

HIV-1 protease has been identified as a significant target enzyme in AIDS research. While numerous peptide-derived inhibitors have been described, the identification of a nonpeptide inhibitor remains an important goal. Using an HIV-1 protease mass screening technique, 4-hydroxy-3-(3-phenoxypropyl)-2H-1- benzopyran-2-one (1) was identified as a nonpeptide competitive inhibitor of the enzyme. Employing a Monte Carlo-based docking procedure, the coumarin was docked in the active site of the enzyme, revealing a binding mode that was later confirmed by the X-ray crystal analysis. Several analogs were prepared to test the binding interactions and improve the overall binding affinity. The most active compound in the study was 4,7-dihydroxy-3-[4-(2- methoxyphenyl)butyl]-2H-1-benzopyran-2-one (31).