1610541-96-2Relevant academic research and scientific papers
HEAVY ATOM LABELED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACID POLYMERS, AND USES THEREOF
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Paragraph 00396, (2014/06/11)
The present disclosure provides compositions and methods to sequence nucleic acid polymers for improving sequencing read length using electron microscopy, e.g., high-resolution scanning transmission electron microscopy (STEM). The present disclosure further provides heavy-atom labeled compounds of Formula (I): nucleic acid polymers comprising one or more heavy-atom labeled units of Formula (II'): such as heavy-atom labeled nucleic acid polymers of Formula (II): and salts thereof, wherein each of G 1, G2, G 3, M 1, M2, Base, and n are as defined herein, optionally for use in the methods described.
