1610559-06-2Relevant academic research and scientific papers
Catalytic Activation of Cis-Vicinal Diols by Boronic Acids: Site-Selective Acylation of Carbohydrates
Shimada, Naoyuki,Nakamura, Yuki,Ochiai, Takayuki,Makino, Kazuishi
supporting information, p. 3789 - 3794 (2019/05/24)
Site-selective acylation of unprotected carbohydrates by using stable, storable, and easily handled imidazole-containing organoboronic acid catalysts is described. This catalytic process with low catalyst loading enables the introduction of a wide variety of acyl functional groups into the equatorial position of cis-vicinal diols in unprotected hexapyranosides with excellent site selectivity. This is the first example that uses a Lewis base-containing boronic acid to enhance the nucleophilicity of hydroxy groups.
Method for triggering hydroxy selective acylation of dihydric alcohol or polyhydric alcohol by catalytic amount of organic amine
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Paragraph 0019, (2018/10/27)
The invention belongs to the field of organic chemical engineering, and particularly provides a method for triggering hydroxy selective acylation of dihydric alcohol or polyhydric alcohol by a catalytic amount of organic amine. According to the method, dihydric alcohol or polyhydric alcohol dissolves in an appropriate amount of organic solvents, a chemical amount of anhydride and the catalytic amount of organic amine are added, N,N-diisopropylethylamine is added particularly, reaction is conducted at the temperature of 0-50 DEG C for 4-12 hours, and high-selectivity acylation on specific hydroxyl can be realized. The method has the advantages that reaction conditions are mild, the method is simple and convenient to operate, inhibitors are green, environmentally friendly, low in cost and easy to get, and the method has wide application value in labs and industries.
Recognition and site-selective transformation of monosaccharides by using copper(II) catalysis
Chen, I-Hon,Kou, Kevin G. M.,Le, Diane N.,Rathbun, Colin M.,Dong, Vy M.
, p. 5013 - 5018 (2014/05/06)
We demonstrate copper(II)-catalyzed acylation and tosylation of monosaccharides. Various carbohydrate derivatives, including glucopyranosides and ribofuranosides, are obtained in high yields and regioselectivities. Using this versatile strategy, the site
