161063-22-5Relevant academic research and scientific papers
A -CH2CH:C+NR2 synthon: Novel preparations of 1,3-disubstituted allylamines and of 1,2-diaryl pyrroles
Katritzky, Alan R.,Chang, He-Xi,Verin, Sergei V.
, p. 343 - 346 (1995)
1-(3-Morpholinoprop-2-enyl)benzotriazole (1) is a useful synthon of the type [-CH2-CH=C+NR2] as demonstrated by the preparation of allylamines 4. It can also provide a [+-CH-CH=CH+] fragment for the synthesis of 1,2-diarylpyrroles 6.
Tyrosine phosphatase inhibitors
-
, (2008/06/13)
A compound of the formula (I): wherein X1 and X2 are the same or different and each is a bond or a spacer having 1 to 20 atom(s) in the main chain; one of R1 and R2 is a cycle group having substituent(s) selected from 1) an optionally substituted carboxy-C1-6 alkoxy group and 2) an optionally substituted carboxy-C1-6 aliphatic hydrocarbon group, wherein the cycle group optionally has additional substituent(s), and the other is an optionally substituted cycle group or a hydrogen atom; and R3, R4 and R5 are the same or different and each is a hydrogen atom or a substituent, or R4 may link together with R3 or R5 to form an optionally substituted ring; provided that when R3 is a hydrogen atom, R4 is a hydrogen atom and R5 is methyl, X2—R2 is not 4-cyclohexylphenyl; when R3 is 4-methoxyphenyl, R4 is a hydrogen atom and R5 is methyl, X2—R2 is not 4-methoxyphenyl; and when R1 or R2 is a hydrogen atom, the adjacent X1 or X2 is not a C1-7 alkylene; or a salt thereof exhibits a protein tyrosine phosphatase inhibitory action and is useful as a prophylactic or therapeutic agent for diabetes or the like.
