1610693-54-3Relevant academic research and scientific papers
One-pot to fused pyrazoles by a double cyclization of o-alkynylaldehydes with ketones and hydrazine under metal-free condition
Qiao, Jinxia,Liu, Bin,Liao, Zongquan,Li, Ying,Ma, Lei,Dong, Chune,Zhou, Hai-Bing
, p. 3782 - 3787 (2014/05/20)
An efficient one-pot synthesis of fused pyrazoles has been developed. The procedure involved three components reaction of o-alkynylaldehydes 1a-s with ketones 2a-m and hydrazine under mild, metal-free reaction conditions. The desired products were obtained in one-step up to 85% yield. The molecular structure was confirmed by the X-ray crystallographic analysis.
