1610730-74-9

Basic information

• Product Name: 2-[(8-phenyl-9H-purin-6-yl)thio]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole
• CAS NO: 1610730-74-9
• Molecular Weight: 440.408
• Mol File: 1610730-74-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[(8-phenyl-9H-purin-6-yl)thio]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(8-phenyl-9H-purin-6-yl)thio]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole(1610730-74-9)
• EPA Substance Registry System: 2-[(8-phenyl-9H-purin-6-yl)thio]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole(1610730-74-9)

Safety Data

• Hazardous Substances Data: 1610730-74-9(Hazardous Substances Data)

Upstream product

• 389120-03-0 5-[4-(Trifluoromethyl)phenyl]-1,3,4-oxadiazole-2-thiol 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors

Rearrangements of anaplastic lymphoma kinase (ALK) are associated with several cancer diseases. Due to resistance development against existing ALK-inhibitors, new, structurally unrelated inhibitors are required. By a scaffold hopping strategy, 6,8-disubstituted purines were designed as analogues of similar ALK-inhibiting thieno[3,2-d]pyrimidines. While the new title compounds indeed inhibited ALK and several ALK mutants in submicromolar concentrations, they retained poor water solubility.