1610792-96-5Relevant academic research and scientific papers
Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination
Ghorai, Samir,Chirke, Sahadev Shrihari,Xu, Wen-Bin,Chen, Jia-Feng,Li, Changkun
, p. 11430 - 11434 (2019)
The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic carbonates bearing alkyl groups with both aromatic and aliphatic amines has been developed. The process allows rapid access of allylic amines in high yields with exclusively branched selectivity and excellent enantioselectivities (normally 99% ee) under mild reaction conditions.
Rh(I)/Bisoxazolinephosphine-Catalyzed Regio- And Enantioselective Allylic Substitutions
Ghorai, Samir,Huang, Wenyu,Li, Changkun,Xu, Wen-Bin
, p. 4491 - 4496 (2020/05/19)
Rhodium(I)/bisoxazolinephosphine combination has been developed as a general catalyst to achieve the dynamic kinetic asymmetric allylation of a variety of nitrogen, carbon, oxygen, and sulfur pronucleophiles from branched racemic allylic carbonates. Exclusive branch-selectivity and up to 99% enantiomeric excess could be obtained under neutral conditions. Linear allylic substrates (both Z and E) could be converted to the same chiral branched products with excellent regio- and enantioselectivities as well. Chiral π-allyl-Rh(III)/NPN intermediate was isolated and characterized to understand the origin of the high selectivities.
