1610846-62-2

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 87-62-7 2,6-dimethylaniline 

Downstream Products

• 219815-74-4 dichloro[2,6-Me₂-N-(2-pyridinylmethylene)phenylamine]Pd(II) 
• 1610846-64-4 2-(2′,6′-dimethylphenyl)imidazo[1,5-a]pyridin-2-ium hexafluorophosphate 
• 221350-30-7 1-(2-pyridyl)-2-(2,6-dimethylphenyl)-2-azaethene-(N-N)-nickel dibromide 

Relevant academic research and scientific papers

The effect of: Cis - Trans configurational difference on the performance of pyridylimine-based ruthenium sensitizers

New heteroleptic Ru(ii) complexes consisting of pyridylimine as an ancillary ligand were synthesized and characterized for applications in dye sensitized solar cells. Complexes with cis and trans configurations around the central ruthenium metal were obtained using simple synthetic protocols by varying the substituents on the pyridylimine ligands. The geometries of these complexes were confirmed by single crystal X-ray analysis. The effect of the difference in the configurations of these complexes on their device performances was studied and the sensitizer with a trans arrangement around the metal showed a higher overall conversion efficiency (η) of 7.27% than that of the cis configured complex (η = 2.04%).

Synthesis, characterization and crystal structure of cationic bis(pyridinylimine)cobalt(II) complexes

Ligands 2,6-dimethyl-N-(pyridin-2-ylmethylene)aniline C14H14N2 (L1), 2,6-dimethyl-N-(1-(pyridin-2-yl)ethylidene)aniline C15H16N2 (L2) and 2,6-diisopropyl-N-(1-(pyridin-2-yl)ethylidene)anili

Synthesis and X-ray Crystal Structures of Zinc Complexes Supported by Chelating Ligands: Various Reactions of α-Iminopyridines with ZnEt2

α-Iminopyridine (α-IP) is an important redox-noninnocent ligand. The substituents on the imino function of α-IPs have important impact on the reaction selectivity with diethylzinc. For the α-IPs with a hydrogen substituent on the imino carbon, reduction o

Silver(I)-pyridinyl Schiff base complexes: Synthesis, structural characterization and reactivity in ring-opening polymerisation of ε-caprolactone

Reactions of AgO2C2F3with 2-pyridinyl Schiff base ligands bore five novel complexes of the type [(AgO2C2F3)2.L2]: where L?=?L1, (E)-N-(1-(pyridin-2-yl)ethylidene)anili

Synthesis and structural elucidation of (pyridyl)imine Fe(II) complexes and their applications as catalysts in transfer hydrogenation of ketones

Reactions of (pyridyl)imine ligands: 2,6-diisopropyl-N-[(pyridine-2-yl)methylene]aniline (L1), 2,6-diisopropyl-N-[(pyridine-2-yl)ethylidene]aniline (L2), 2,6-dimethyl-N-[(pyridine-2-yl)methylene]aniline (L3), 2,6-dimethyl-N-[(pyridine-2-yl)ethylidene]aniline (L4) and N-[(pyridine-2-yl)methylene]aniline (L5) with FeCl2 salt afforded the corresponding paramagnetic Fe(II) complexes [Fe(L1)2Cl][FeCl4] (Fe1), [Fe(L2)2Cl][FeCl4] (Fe2), [Fe(L3)2Cl][FeCl4] (Fe3), [Fe(L4)2Cl][FeCl4], (Fe4), [Fe(L5)2Cl2] (Fe5) in good yields. On the other hand, reactions of L1 with FeCl2 in the presence of NaPF6 afforded complex [Fe(L1)2Cl][PF6] (Fe6) in moderate yields. Molecular structures of complexes Fe1 and Fe2 reveal the formation of cationic species containing two N^N bidentate ligands and one chlorido co-ligand to give five-coordinate geometry with [FeCl4]? as counter-anion. On the other hand, complex Fe5, is an octahedral neutral species containing two bidentate L5 and two chlorido ligands. All the complexes (Fe1–Fe6) formed active catalysts in the transfer hydrogenation of ketones affording average yields of about 85%. The ligand architecture, reaction conditions and nature of substrate influenced the catalytic activities of the complexes. Mercury and subs-stoichiometric poisoning tests pointed to the existence of both Fe(0) nanoparticles and homogeneous Fe(II) species as the active intermediates.

Highly active iminopyridyl iron-based catalysts for the polymerization of isoprene

A series of iminopyridyl-based ligands, 6-[(Ar)N=C(R)]-2-C6H5N [(Ar = 2,6-Me2-C6H3, R = Me (L1); Ar = 2,6-iPr2-C6H3, R = Me (L2); Ar = 2,6-Me2-C6H3, R = H (

Palladium(II) complexes containing N,N′-bidentate imine ligands derived from picolinaldehyde and substituted anilines: Synthesis, structure and polymerisation of methyl methacrylate

Palladium(II) complexes, LnPdCl2 (Ln = LA–LI), with N,N′-bidentate imine ligands derived from picolinaldehyde and substituted anilines have been synthesized and structurally characterized. Molecular structures revealed a distorted square plane geometry around Pd(II) centre in LnPdCl2 (Ln = LA–LC) obtained via coordination with pyridine and imine nitrogens and two chloro ligands. Pd(II) complexes LnPdCl2 (Ln = LA–LI) initiate polymerisation of methylmethacrylate (MMA) in the presence of modified methylaluminoxane (MMAO). The complex LIPdCl2 (of which the ligand was N-furfuryl substituted) showed the highest catalytic activity for the polymerisation of MMA with an activity of 7.08 × 104 g PMMA/mol·Pd·h at 60 °C. All the complexes yielded syndio-rich poly(methyl methacrylate) (PMMA) ([rr] = 0.70). Notably, the substituents on the imine moiety of the iminopyridine fragments affects the activities towards MMA polymerization, whereas the stereoselectivities remained unchanged.

Lysosome-Targeted Chemotherapeutics: Half-Sandwich Ruthenium(II) Complexes That Are Selectively Toxic to Cancer Cells

Poor selectivity between cancer cells and normal cells is one of the major limitations of cancer chemotherapy. Lysosome-targeted ruthenium-based complexes target tumor cells selectively, only displaying rather weak cytotoxicity or inactivity toward normal cells. Confocal microscopy was employed for the first time to determine the cellular localization of the half-sandwich Ru complex.

Silver(I)-pyridinyl Schiff base complexes: Synthesis, characterisation and antimicrobial studies

Fifteen new silver(I)-pyridinyl complexes of the general formula [AgL2]X, where X = ClO4?, OTf or NO3?, were synthesised by reacting (E)-N-(pyridinylmethylene)aniline ligands and the respective silver

Novel half-sandwich iridium(iii) imino-pyridyl complexes showing remarkable: In vitro anticancer activity

Seven novel half-sandwich IrIII cyclopentadienyl complexes, [(η5-Cpx)Ir(N^N)Cl]PF6, have been prepared and characterized, where Cpx is Cp? or the biphenyl derivative Cpxbiph (C5Me4C6H4C6H5), and the N^N-chelating ligands are imino-pyridyl Schiff-bases. The X-ray crystal structures of complexes 2A, 2B, and 3A have been determined. Excitingly, most of the complexes show potent antiproliferative activity towards A549 and HeLa cancer cells, except for Cp? complex 1A towards HeLa cells. Cpxbiph complex 2B displayed the highest potency, about 19 and 6 times more active than the clinically used drug cisplatin toward A549 and HeLa cells, respectively. These complexes undergo hydrolysis, and the kinetics data have been calculated. DNA binding has been studied by interaction with nucleobases 9-ethylguanine and 9-methyladenine, cleavage of plasmid DNA, and interaction with ctDNA. Interaction with DNA does not appear to be the major mechanism of action. Protein binding (bovine serum albumin, BSA) has been established by UV-Vis, fluorescence and synchronous spectroscopic studies. The stability of complex 2B in the presence of GSH was evaluated. The complexes catalytically convert coenzyme NADH to NAD+via hydride transfer. Cpxbiph complexes 2B and 4B induce cell apoptosis and arrest cell cycles at the S and G2/M phases towards A549 cancer cells and increase the reactive oxygen species dramatically, which appear to contribute to the remarkable anticancer activity.