1610888-99-7

Basic information

• Product Name: (E)-4-(1,3-dithian-2-ylidene)-5,5,5-trifluoro-1-phenylpent-1-en-3-one
• Synonyms: (E)-4-(1,3-dithian-2-ylidene)-5,5,5-trifluoro-1-phenylpent-1-en-3-one
• CAS NO: 1610888-99-7
• Molecular Weight: 330.395
• Mol File: 1610888-99-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-4-(1,3-dithian-2-ylidene)-5,5,5-trifluoro-1-phenylpent-1-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(1,3-dithian-2-ylidene)-5,5,5-trifluoro-1-phenylpent-1-en-3-one(1610888-99-7)
• EPA Substance Registry System: (E)-4-(1,3-dithian-2-ylidene)-5,5,5-trifluoro-1-phenylpent-1-en-3-one(1610888-99-7)

Safety Data

• Hazardous Substances Data: 1610888-99-7(Hazardous Substances Data)

Upstream product

• 1142319-66-1 C₁₄H₁₄OS₂ 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 6784-58-3 1-(1,3-dithian-2-ylidene)propan-2-one 

Relevant articles and documents

Copper-catalyzed trifluoromethylation of internal olefinic C-H bonds: Efficient routes to trifluoromethylated tetrasubstituted olefins and N-heterocycles

The functionalization of internal olefins has been a challenging task in organic synthesis. Efficient CuII-catalyzed trifluoromethylation of internal olefins, that is, α-oxoketene dithioacetals, has been achieved by using Cu(OH)2 as a catalyst and TMSCF3 as a trifluoromethylating reagent. The push-pull effect from the polarized olefin substrates facilitates the internal olefinic C-H trifluoromethylation. Cyclic and acyclic dithioalkyl α-oxoketene acetals were used as the substrates and various substituents were tolerated. The internal olefinic C-H bond cleavage was not involved in the rate-determining step, and a mechanism that involves radicals is proposed based on a TEMPO-quenching experiment of the trifluoromethylation reaction. Further derivatization of the resultant CF 3 olefins led to multifunctionalized tetrasubstituted CF3 olefins and trifluoromethylated N-heterocycles.