1610930-19-2Relevant academic research and scientific papers
Synthesis and in vitro cytotoxic activities of sorafenib derivatives
Wang, Ke,Li, Yan,Zhang, Li-Jing,Chen, Xiao-Guang,Feng, Zhi-Qiang
supporting information, p. 702 - 704 (2014/06/09)
A series of novel sorafenib derivatives have been designed and synthesized. The cytotoxic activities of these compounds were tested in three tumor cell lines. Most of the compounds showed potent antiproliferative activity against the tested cell lines with IC50 = 0-20 μmol/L. Some compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines. Among them, compound 5g demonstrated significant inhibitory activity against A549, ACHN and MDA-MB-231 cell lines with IC 50 values of 1.29, 1.99, 3.11 μmol/L, respectively.
