1611-64-9Relevant academic research and scientific papers
THE HOFMANN REARRANGEMENT INDUCED BY ELECTROORGANIC METHOD
Shono, Tatsuya,Matsumura, Yoshihiro,Yamane, Shin-ichiro,Kashimura, Shigenori
, p. 565 - 568 (1982)
The Hofmann rearrangement has been induced by the electroorganic method using potassium bromide as a mediator, of which role in the reaction is really catalytic.
SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME
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Paragraph 0703, (2019/02/15)
The present disclosure relates to compounds of Formula (I): (I); and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: A change in direction in the search for a second generation HCV NS3 protease inhibitor
Bennett, Frank,Huang, Yuhua,Hendrata, Siska,Lovey, Raymond,Bogen, Stephane L.,Pan, Weidong,Guo, Zhuyan,Prongay, Andrew,Chen, Kevin X.,Arasappan, Ashok,Venkatraman, Srikanth,Velazquez, Francisco,Nair, Latha,Sannigrahi, Mousumi,Tong, Xiao,Pichardo, John,Cheng, Kuo-Chi,Girijavallabhan, Viyyoor M.,Saksena, Anil K.,Njoroge, F. George
scheme or table, p. 2617 - 2621 (2010/07/05)
In the search for a second generation HCV protease inhibitor, molecular modeling studies of the X-ray crystal structure of Boceprevir 1 bound to the NS3 protein suggest that expansion into the S4 pocket could provide additional hydrophobic Van der Waals interactions. Effective replacement of the P4 tert-butyl with a cyclohexylmethyl ligand led to inhibitor 2 with improved enzyme and replicon activities. Subsequent modeling and SAR studies led to the pyridine 38 and sulfone analogues 52 and 53 with vastly improved PK parameters in monkeys, forming a new foundation for further exploration.
SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
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Page/Page column 376, (2010/11/03)
The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.
SYNTHESIS OF ALIPHATIC ISOCYANATES VIA A TWO-PHASE HOFMANN REACTION
Sy, Anita O.,Raksis, Joseph W.
, p. 2223 - 2226 (2007/10/02)
A convenient method of preparing aliphatic isocyanates via a two-phase Hofmann reaction using a phase transfer catalyst is described.
