16110-89-7

Usage

InChI:InChI=1/C9H6Cl2N4O3S/c10-7-13-8(11)15-9(14-7)12-5-1-3-6(4-2-5)19(16,17)18/h1-4H,(H,16,17,18)(H,12,13,14,15)

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 121-57-3 4-aminobenzene sulfonic acid 

Downstream Products

• 360049-55-4 C₁₅H₁₂ClN₅O₆S₂ 
• 58557-51-0 C₁₉H₁₄ClN₅O₁₀S₃ 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions

The third variable loop region (V3 loop) on gp120 plays an important role in cellular entry of HIV-1. Its interaction with the cellular CD4 and coreceptors is an important hallmark in facilitating the bridging by gp41 and subsequent fusion of membranes for transfer of viral genetic material. Further, the virus phenotype determines the cell tropism via respective co– receptor binding. Thus, coreceptor binding motif of envelope is considered to be a potent anti-viral drug target for viral entry inhibition. However, its high variability in sequence is the major hurdle for developing inhibitors targeting the region. In this study, we have used an in silico Virtual Screening and “Fragment-based” method to design small molecules based on the gp120 V3 loop interactions with a potent broadly neutralizing human monoclonal antibody, 447-52D. From the in silico analysis a potent scaffold, 1,3,5-triazine was identified for further development. Derivatives of 1,3,5-triazine with specific functional groups were designed and synthesized keeping the interaction with co-receptor intact. Finally, preliminary evaluation of molecules for HIV-1 inhibition on two different virus strains (clade C, clade B) yielded IC50 5.0 μM. The approach used to design molecules based on broadly neutralizing antibody, was useful for development of target specific potent antiviral agents to prevent HIV entry. The study reported promising inhibitors that could be further developed and studied.

A new way to improve the light-fastness of azo reactive dyes through the introduction of benzene sulfonamide derivatives into the triazine ring

Herein, a new kind of hetero-bifunctional reactive dyes with high light-fastness was designed and synthesized by introducing benzene sulfonamide and its derivatives into the triazine ring. Benzene sulfonamide or its derivatives and 2-amino-5-naphthol-7-sulfonic acid (J-acid) were condensed with cyanuric chloride to synthesize coupling components, which were then coupled with the diazo salt of 4-(β-sulfatoethylsulfonyl)aniline. The dyes were characterized by IR spectroscopy and MS. The color fastness test proved that the light-fastness of the dyes could be improved by 1 grade via the introduction of benzene sulfonamide derivatives into the triazine ring when compared with the case of the control dyes. Fluorescence spectra demonstrated that after the introduction of benzene sulfonamide derivatives, the dye molecule could return to the ground state from the excited state and emit fluorescence; in addition, the introduced benzene sulfonamide derivatives helped to deteriorate the adverse effect of UV light on the dye. Moreover, the dyeing results showed that the dyes containing the sulfonamide groups had equal dyeing properties when compared with that of the control dyes.

URACIL COMPOUND OR SALT THEREOF, AND PIGMENT COMPOSITION CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide a composition stable as a colorant of e.g., a resist for color filters, where a pigment composition containing an organic pigment is reduced in particle size and increased in concentration without causing aggregation, sedimentation, or a viscosity increase with time. SOLUTION: The present invention provides a uracil compound represented by a formula (1) or a salt thereof (X, Y and Z are O, S or a bivalent linking group -NR1-; R1 is H or a C1-4 alkyl group; R2 is a phenyl group or a naphthylene group having sulfonic acid or sulfonic acid salt as a substituent). SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

COUMARIN COMPOUND OR SALT THEREOF, AND PIGMENT COMPOSITION COMPRISING THE SAME

PROBLEM TO BE SOLVED: To provide a composition stable as a colorant of a resist for a color filter or the like, which is prepared into fine particles and into a high concentration from a pigment composition comprising an organic pigment without inducing aggregation, sedimentation, or increase in viscosity with time. SOLUTION: The present invention provides a coumarin compound having a structure represented by formula (1) or a salt thereof, and a pigment composition comprising the compound. In the formula, R1 and R2 each independently represent H or an alkyl group having 1 to 4 carbon atoms; R3 to R6 each independently represent H, an alkyl group having 1 to 4 carbon atoms, or the like; M represents H, an alkali metal atom, or the like; and X and Y represent O, S or a divalent connecting group -NR7-, where R7 represents H or an alkyl group having 1 to 4 carbon atoms. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPO&INPIT

BENZIMIDAZOLONE COMPOUND OR SALT THEREOF, AND PIGMENT COMPOSITION CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide a stable composition as a colorant of a resist for color filters and the like, wherein a pigment composition containing an organic pigment is atomized and increased in concentrations without aggregation, sedimentation, or increased viscosity with time. SOLUTION: The present invention provides a benzimidazolone compound represented by formula (1) or a salt thereof (M is H, an alkali metal atom or a -NZ1Z2Z3Z4 group; Z1-Z4 independently represent H, a C1-4 alkyl group, a C1-4 hydroxyalkyl group, an aralkyl group, a C1-4 cycloalkyl group, an aryl group, or a C1-4 alkyl group having a C1-6 cycloalkyl group as a substituent; X-Z independently represent O, S or -NR1-; R1 is H or a C1-4 alkyl group). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Preparation method of liquid fluorescent whitening agent used for papermaking

The invention relates to a preparation method of a symmetrical and asymmetrical triazinylstilbene liquid fluorescent whitening agent composition used for papermaking and represented by structural formulas (V), (VI) and (VII). The liquid fluorescent whitening agent composition is prepared from cyanuric chloride, sulfanilic acid, 4,4-diaminostilbene-2,2-disulfonic acid and a diethanolamine and diethylamine mixture through a three-step condensation reaction and nanofiltration membrane filtering process desalination and filtration treatment. The liquid fluorescent whitening agent composition has the advantages of excellent cation interference resistance, large solubility in a surface sizing agent, compounding synergy effect, better whitening effect than single components, high whiteness and small dosage when applied in the papermaking surface sizing process; and the composition has lower comprehensive cost than hexasulfonica cid type fluorescent whitening agents specially used for surface sizing, and has high cost performance.

A reactive halo amine antibacterial agent and its preparation method and application

The invention discloses a reaction type halamine antiseptic. The structural formula of the antiseptic is represented in the description. In the structural formula, the R represents F or Cl, and the R1 and R2 individually represent Cl or Br. The preparation method comprises the following steps: (1) in an alkaline condition, reacting 5,5-dimethylhydantoin with 3-chloro-1-propanol to generate 3-hydroxypropyl-5,5-dimethylhydantoin; (2) carrying out one-step reaction between sodium sulfanilate and 3-hydroxypropyl-5,5-dimethylhydantoin to obtain a halamine antiseptic precursor (II); (3) reacting the halamine antiseptic precursor (II) with sodium hypochlorite so as to obtain the finished product of halamine antiseptic. The chlorine content of the textile processed by the antiseptic can reach 0.35%, the sterilizing rate on staphylococcus aureus can reach 100% in 10 minutes, and the sterilizing rate on escherichia coli O157:H7 can reach 100% within one minute. The operation is simple during the whole synthesis process, no toxic byproduct is generated, and the synthesis raw materials are cheap.

DIKETOPYRROLOPYRROLE COMPOUND OR ITS SALT, AND PIGMENT COMPOSITION COMPRISING THE SAME

PROBLEM TO BE SOLVED: To provide a stable pigment composition comprising an organic pigment having a diketopyrrolopyrrole skeleton, which is prepared in a fine particle state with a high concentration while preventing aggregation, sedimentation, increase in the viscosity with time, or the like. SOLUTION: The pigment composition comprises a diketopyrrolopyrrole compound represented by formula (1) below. In formula (1), n represents an integer of 1 or 2; R1 represents H, an alkyl group having 1 to 4 carbon atoms, or a halogen atom; R2 and R3 each independently represent H or an alkyl group having 1 to 4 carbon atoms; R4 represents H, an alkyl group having 1 to 4 carbon atoms, or a hydroxyalkoxyalkyl group having 2 to 8 carbon atoms; X, Y, Z each independently represent O, S or -NR5-; and R5 represents H, an alkyl group having 1 to 4 carbon atoms, or a hydroxyalkoxyalkyl group having 2 to 8 carbon atoms. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

A new kind of H-acid monoazo-anthraquinone reactive dyes with surprising colour

A new kind of reactive dyes containing both monoazo and anthraquinone chromophores was obtained by using 1,4-bis((4-aminophenyl)amino)anthrancene- 9,10-dione as diazo component and 1-amino-8-naphthol-3,6-disulfonicacid (H-acid) derivatives as coupling components. The dyes were characterized by UV-Vis, IR, MS, 1H NMR and 13C NMR. The results showed that the maximum absorption wavelengths of the dyes were all about 590 nm, which indicated that they were a kind of blue dyes. 1H NMR and 13C NMR results revealed that there were two kinds of tautomerisms in dye structure and a new conjugated system formed between the anthraquinone ring and the phenyl azo linkage. Density functional theory (DFT) calculations also proved the formation of the new larger conjugated system from which the blue colour was generated. The fixations of the dyes on cotton were over 88% and the light fastness reached 5 grade.

PORPHYRAZINE DYE, INK, INK SET, AND COLORED MATTER

The present invention relates to a porphyrazine coloring matter represented by the following formula (1): (wherein, A, B, C and D independently represents a 6-membered ring having aromaticity, at least one or more is a benzene ring, at least one or more contains a nitrogen-containing heteroaromatic ring; in addition, E represents alkylene and each of X and Y independently represents a substituted or unsubstituted anilino group or a substituted or unsubstituted naphthylamino group; and b is 0 to 2.9, c is 0.1 to 3 and the sum of b and c is 1 to 3) which has a good hue as a cyan ink, is excellent in light fastness, ozone fastness and moisture fastness, and does not cause bronze phenomenon, as well as is thus suitable for inkjet recording.