161106-42-9

Basic information

• Product Name: (4R)-4-Isobutyl-2-oxazolidinone
• Synonyms: (4R)-4-Isobutyl-2-oxazolidinone;2-Oxazolidinone, 4-(2-methylpropyl)-, (R)- (9CI)
• CAS NO: 161106-42-9
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.18362
• Mol File: 161106-42-9.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4R)-4-Isobutyl-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-4-Isobutyl-2-oxazolidinone(161106-42-9)
• EPA Substance Registry System: (4R)-4-Isobutyl-2-oxazolidinone(161106-42-9)

Safety Data

• Hazardous Substances Data: 161106-42-9(Hazardous Substances Data)

Usage

Description

(4R)-4-Isobutyl-2-oxazolidinone, also known as Isoxsuprine, is a chemical compound belonging to the class of oxazolidinone compounds. It possesses potential pharmacological properties and is commonly used as a vasodilator to improve blood flow in certain medical conditions.

Uses

Used in Cardiovascular Medicine:
(4R)-4-Isobutyl-2-oxazolidinone is used as a vasodilator for improving blood flow in conditions such as peripheral vascular disease, arteriosclerosis, and Raynaud's disease. It works by relaxing and widening the blood vessels, which in turn increases blood flow to certain parts of the body.
Used in Obstetric Medicine:
(4R)-4-Isobutyl-2-oxazolidinone is used as a uterine relaxant in obstetric medicine to improve blood flow to the placenta in cases of preterm labor. This helps in reducing the risk of complications associated with preterm birth.
(4R)-4-Isobutyl-2-oxazolidinone has been found to be generally well-tolerated with minimal side effects when used as directed by a healthcare professional.

Upstream product

• 3647-37-8 2-isobutyl-aziridine 
• 124-38-9 carbon dioxide 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 105-58-8 Diethyl carbonate 
• 19213-72-0 ethyl 1-imidazolecarboxylate 
• 16369-17-8 2-amino-4-methylpentan-1-ol 
• 98433-24-0 2-hydroxymethyl-4-methyl-pentanoic acid hydrazide 
• 14438-11-0 L-leucinol 
• 201230-82-2 carbon monoxide 
• 1888-75-1 isopropyllithium 
• 154669-49-5 [(S)-2-oxooxazolidin-4-yl]methyl-4-methylbenzenesulfonate 
• 332-25-2 4-(trifluoromethoxy)benzonitrile 
• 616-38-6 carbonic acid dimethyl ester 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 155727-84-7 (4S)-4-isobutyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one 
• 1542980-49-3 3-[(1R,2S,4S)-7-benzyloxycarbonyl-7-azabicyclo[2.2.1]heptane-2-carbonyl]-(4S)-(2-methylpropyl)-2-oxazolidinone 
• 1542980-63-1 3-[(1S,2R,4R)-7-benzyloxycarbonyl-7-azabicyclo[2.2.1]heptane-2-carbonyl]-(4S)-(2-methylpropyl)-2-oxazolidinone 
• 70468-82-5 {4-[2-methyl-1-(2-oxo-oxazolidin-4-yl)-propoxy]-phenethyl}-carbamic acid benzyl ester 
• 70468-83-6 {4-[2-methyl-1-(2-oxo-oxazolidin-4-yl)-propoxy]-phenethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Sequencing of Sequence-Defined Oligourethanes via Controlled Self-Immolation

Sequence-defined polymers show promise for biomimetics, self-assembly, catalysis, and information storage, wherein the primary structure begets complex chemical processes. Here we report the solution-phase and the high-yielding solid-phase syntheses of discrete oligourethanes and methods for their self-immolative sequencing, resulting in rapid and robust characterization of this class of oligomers and polymers, without the use of MS/MS. Crucial to the sequencing is the inherent reactivity of the terminal alcohol to "unzip" the oligomers, in a controlled and iterative fashion, releasing each monomer as a 2-oxazolidinone. By monitoring the self-immolation reaction via LC/MS, an applied algorithm rapidly produces the sequence of the oligourethane. Not only does this process provide characterization of structurally complex molecules, it works as a reader of molecular information.

N-Acylation of Oxazolidinones via Aerobic Oxidative NHC Catalysis

The first N-acylation of synthetically useful oxazolidinones with aldehydes using aerobic oxidative NHC catalysis is reported. The reaction offers a broad scope of functionalized oxazolidinones in good to excellent yields. Careful choice of electron transfer mediators proved pivotal to achieve efficient aerobic N-acylation, which has previously proven difficult using NHC catalysis. The methodology allows a mild entry to acylated oxazolidinones, avoiding the use of hazardous and reactive prefunctionalized substrates.

Method of preparing oxazolidone

The invention discloses a method of preparing oxazolidone. The method uses aziridine and carbon dioxide as materials and imidazole ionic liquid modified Salen metal complex comprising polyether chains as a catalyst, and allows high-efficiency and high-selectivity catalytic synthesis of oxazolidone under a pressure of 0.1-2.0 Mpa at a temperature of 30-70 DEG C; the process has relatively mild reaction conditions, there is no need for any solvent or co-catalyst, and reaction time is short; in addition, the catalyst provided herein can form a homogeneous catalytic system with a substrate under certain temperature and pressure, and by adding the solvent, it is possible to separate from the reaction system to enable reuse.