161106-42-9Relevant articles and documents
Sequencing of Sequence-Defined Oligourethanes via Controlled Self-Immolation
Anslyn, Eric V.,Coronado, Jaime N.,Dahlhauser, Samuel D.,Escamilla, P. Rogelio,Glass, Samuel A.,Moor, Sarah R.,Rapagnani, Rachel M.,Saunders, Douglas P.,Shei, Jasper S.,Vandewalle, Abigail N.,York, Jordan T.
supporting information, p. 2744 - 2749 (2020/03/10)
Sequence-defined polymers show promise for biomimetics, self-assembly, catalysis, and information storage, wherein the primary structure begets complex chemical processes. Here we report the solution-phase and the high-yielding solid-phase syntheses of discrete oligourethanes and methods for their self-immolative sequencing, resulting in rapid and robust characterization of this class of oligomers and polymers, without the use of MS/MS. Crucial to the sequencing is the inherent reactivity of the terminal alcohol to "unzip" the oligomers, in a controlled and iterative fashion, releasing each monomer as a 2-oxazolidinone. By monitoring the self-immolation reaction via LC/MS, an applied algorithm rapidly produces the sequence of the oligourethane. Not only does this process provide characterization of structurally complex molecules, it works as a reader of molecular information.
N-Acylation of Oxazolidinones via Aerobic Oxidative NHC Catalysis
Ta, Linda,Axelsson, Anton,Sundén, Henrik
, p. 12261 - 12268 (2018/09/25)
The first N-acylation of synthetically useful oxazolidinones with aldehydes using aerobic oxidative NHC catalysis is reported. The reaction offers a broad scope of functionalized oxazolidinones in good to excellent yields. Careful choice of electron transfer mediators proved pivotal to achieve efficient aerobic N-acylation, which has previously proven difficult using NHC catalysis. The methodology allows a mild entry to acylated oxazolidinones, avoiding the use of hazardous and reactive prefunctionalized substrates.
Method of preparing oxazolidone
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Paragraph 0027; 0028, (2017/02/09)
The invention discloses a method of preparing oxazolidone. The method uses aziridine and carbon dioxide as materials and imidazole ionic liquid modified Salen metal complex comprising polyether chains as a catalyst, and allows high-efficiency and high-selectivity catalytic synthesis of oxazolidone under a pressure of 0.1-2.0 Mpa at a temperature of 30-70 DEG C; the process has relatively mild reaction conditions, there is no need for any solvent or co-catalyst, and reaction time is short; in addition, the catalyst provided herein can form a homogeneous catalytic system with a substrate under certain temperature and pressure, and by adding the solvent, it is possible to separate from the reaction system to enable reuse.