16112-24-6

Basic information

• Product Name: 1,2,4-Oxadiazole, 5-(4-methylphenyl)-3-phenyl-
• Synonyms: 3-phenyl-5-p-tolyl-[1,2,4]oxadiazole;3-(4-methyl)phenyl-5-phenyl-[1,2,4]oxadiazole;3-phenyl-5-(4-methylphenyl)-1,2,4-oxadiazole;1,2,4-Oxadiazole,5-(4-methylphenyl)-3-phenyl;3-Phenyl-5-p-tolyl-[1,2,4]oxadiazol
• CAS NO: 16112-24-6
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Mol File: 16112-24-6.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazole, 5-(4-methylphenyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole, 5-(4-methylphenyl)-3-phenyl-(16112-24-6)
• EPA Substance Registry System: 1,2,4-Oxadiazole, 5-(4-methylphenyl)-3-phenyl-(16112-24-6)

Safety Data

• Hazardous Substances Data: 16112-24-6(Hazardous Substances Data)

Upstream product

• 873-67-6 benzonitrile oxide 
• 104-85-8 para-methylbenzonitrile 
• 1165952-91-9 cyclohexa-1,3-diene 
• 186665-01-0 3-phenyl-5-p-tolyl-1,2,4-oxadiazole-4-oxide 
• 613-92-3 N-hydroxyl-benzamidine 
• 99-94-5 p-Toluic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 100-47-0 benzonitrile 
• 100-52-7 benzaldehyde 
• 932-90-1 Benzaldoxime 
• 698-16-8 benzohydroximoyl chloride 
• 104-84-7 para-methylbenzylamine 
• 68167-55-5 benzimidoyl-p-toluoyl-amine 

Downstream Products

• 65965-65-3 4-[s-triazolo[1,5-a]pyrid-2-yl]-4'-(3-phenyl-1,2,4-oxadiazol-5-yl)-stilbene 
• 68699-90-1 3-{4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-trans-styryl]-phenyl}-benzo[d]isoxazole 
• 72094-38-3 4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-benzaldehyde 
• 72093-55-1 5-{4-[2-chloro-4-(4,5-diphenyl-oxazol-2-yl)-trans-styryl]-phenyl}-3-phenyl-[1,2,4]oxadiazole 
• 72093-86-8 2-{3-chloro-4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-trans-styryl]-phenyl}-benzooxazole 
• 72093-85-7 5-methyl-2-{4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-styryl]-phenyl}-benzooxazole 
• 64893-57-8 2-{4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-trans-styryl]-phenyl}-benzooxazole 
• 72094-15-6 5-{4-[4-(5-biphenyl-4-yl-[1,3,4]oxadiazol-2-yl)-2-chloro-trans-styryl]-phenyl}-3-phenyl-[1,2,4]oxadiazole 
• 72094-14-5 5-(4-{2-chloro-4-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-trans-styryl}-phenyl)-3-phenyl-[1,2,4]oxadiazole 
• 72094-13-4 5-(4-{2-chloro-4-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-trans-styryl}-phenyl)-3-phenyl-[1,2,4]oxadiazole 
• 72094-12-3 5-{4-[2-chloro-4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-trans-styryl]-phenyl}-3-phenyl-[1,2,4]oxadiazole 
• 72094-22-5 2-{3-chloro-4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-trans-styryl]-phenyl}-2H-benzo[1,2,3]triazole 
• 72094-39-4 4-chloro-N-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-benzylidene]-aniline 
• 72094-37-2 5-(4-bromomethyl-phenyl)-3-phenyl-[1,2,4]oxadiazole 

Relevant articles and documents

Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization

A convenient and efficient method for the generation of the iminoxy radical through anodic oxidation was developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles fromN-benzyl amidoximes. The transformation proceeds through 1.5-Hydrogen Atom Transfer (1,5-HAT) and intramolecular cyclization. The process features simple operation, mild conditions, broad substrate scope and high functional group compatibility, and provides a facile and practical way for the preparation of 1,2,4-oxadiazoles.

Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).

TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond

Abstract: A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri-dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec-tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.