161126-48-3Relevant academic research and scientific papers
SUBSTITUTED OXADIAZOLE DERIVATIVES AS S1P AGONISTS IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
-
Page/Page column 95-96, (2010/08/08)
Disclosed are compounds of Formula (I) [INSERT CHEMICAL STRUCTURE HERE] (I) or pharmaceutically acceptable salts thereof, wherein Q is [INSERT CHEMICAL STRUCTURE HERE] or [INSERT CHEMICAL STRUCTURE HERE]; R1 is alkyl or aryl, said aryl optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
SYNTHESIS OF ISOXAZOLES BEARING METHOXYCARBONYL AND FORMYL GROUPS BY 1,3-DIPOLAR CYCLOADDITION OF NITRILE OXIDES TO OLEFINIC AND ACETYLENIC DIPOLAROPHILES
Farina, Francisco,Fraile, M. Teresa,Martin, M. Rosario,Martin, M. Victoria,Guerenu, Ana Martinez de
, p. 285 - 292 (2007/10/02)
The 1,3-dipolar cycloaddition of benzo-, bromoformo- and acetonitrile oxides to enamino ester (1) and acetylenic esters (2,3) afforded functionalized isoxazoles in moderate to good yields.Cycloadditions with the enamino ester (1) gave the corresponding me
