161139-70-4Relevant academic research and scientific papers
Iodine-mediated one-pot synthesis of indoles and 3-dimethylaminoindoles via annulation of enaminones
Jerezano, Alberto V.,Labarrios, Ehecatl M.,Jimenez, Fabiola E.,Del Cruz, Maria Carmen,Pazos, Diana C.,Gutierrez, Rsuini U.,Delgado, Francisco,Tamariz, Joaquin
, p. 18 - 53 (2014/03/21)
The synthesis of 2-carbonylindoles was achieved via a iodine-mediated cyclization of the corresponding enaminone precursors, which were formed by reaction of the ?-arylaminomethylene carbonyl derivatives with N,N'-dimethylformamide dimethyl acetal (DMFDMA). An alternative and more efficient procedure consisted of a similar cyclization of the enaminones, but under solvent-free and grinding reaction conditions. In another iodine-promoted procedure, 2-carbonyl-3-dimethylaminoindoles were synthesized via a one-pot cascade reaction between the α-arylaminomethylene carbonyl derivative and DMFDMA.ARKAT-USA, Inc.
Synthesis of Activated 3-Arylindoles
Black, David St. C.,Bowyer, Michael C.,Bowyer, Paul K.,Ivory, Andrew J.,Kim, Mihyong,et al.
, p. 1741 - 1750 (2007/10/02)
A wide range of substituted 3-aryl-4,6-dimethoxyindoles (6) has been synthesized from the related α-anilinoacetophenones (5), in which the nitrogen atom is protected by a trifluoroacetyl or acetyl group.This method has led to the synthesis of a 3,7'-biindolyl (12).
