1611441-29-2

Upstream product

• 1074-82-4 potassium phtalimide 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 1611441-11-2 2-((2-bromo-1H-indol-3-yl)methyl)isoindoline-1,3-dione 
• 313545-72-1 2-chloro-4-fluorophenylboronic acid 
• 68769-69-7 2-((1H-indol-3-yl)methyl)isoindoline-1,3-dione 

Downstream Products

• 1611441-41-8 (2-(2-chloro-4-fluorophenyl)-1-(isopropylsulfonyl)-1H-indol-3-yl)methanamine 
• 1611441-35-0 C₂₆H₂₀ClFN₂O₄S 

Relevant academic research and scientific papers

Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold

Dipeptidyl peptidase IV (DPP4) inhibitors are proven in the treatment of type 2 diabetes. We designed and synthesized a series of novel indole compounds that selectively inhibit the activity of DPP4 over dipeptidyl peptidase 9 (DPP9) (>200 fold). We further co-crystallized DPP4 with indole sulfonamide (compound 1) to confirm a proposed binding mode. Good metabolic stability of the indole compounds represents another positive attribute for further development.