1611461-94-9

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 894855-52-8 ethyl 4-phenyl-2-(n-propyl)-2,3-butadienoate 

Downstream Products

• 1611462-25-9 (E)-1-(4-chlorophenyl)-4-(hydroxymethyl)-2-phenylhept-1-en-3-one 
• 1611462-22-6 ethyl 5-([1,1'-biphenyl]-4-yl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate 
• 1611462-23-7 (E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate 
• 1611462-24-8 (E)-ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-(prop-2-ynyl)-2-propylpent-4-enoate 

Relevant academic research and scientific papers

Metal alkoxide promoted regio- and stereoselective Ci=O and Ci=C metathesis of allenoates with aldehydes

The reaction of 2,3-allenoates and aldehydes in the presence of an alkoxide affords alkyl 4,5-diaryl-3-oxo-2-propylpent-4(E)-enoates and cis-3,4-diaryloxetanes through a formal Ci=O and Ci=C metathesis. A mechanism for this reaction has been proposed. All'ene' all: The reaction of aldehydes with 2,3-allenoates in the presence of tBuOM (M=Li or Na) affords the stereodefined, highly functionalized γ,δ-unsaturated β-ketoesters 1 in good to excellent yields with E stereoselectivity. The reactivity of 5-hydroxy-2,3-allenoates and the isolation of 3,4-diaryloxetanes led to a rationale for the mechanism of the reaction.