ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate

Base Information

• Chemical Name: ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate
• CAS No.: 1611461-94-9
• Molecular Formula: C₂₂H₂₃ClO₃
• Molecular Weight: 370.876
• Mol file: 1611461-94-9.mol

Synonyms:ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate

Chemical Property of ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate

There total 1 articles about ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-chlorobenzaldehyde (104-88-1) + ethyl 4-phenyl-2-(n-propyl)-2,3-butadienoate (894855-52-8) → ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate (1611461-94-9)

Guidance literature:

With lithium tert-butoxide; In tetrahydrofuran; at 50 ℃; for 2h; Time; Reagent/catalyst; Concentration; Temperature; Solvent; stereoselective reaction;

DOI:10.1002/anie.201310183

Reference yield: 99.0%

allyl iodid (556-56-9) + ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate (1611461-94-9) → (E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate (1611462-23-7)

Guidance literature:

ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

allyl iodid; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 17.0833h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201310183

Reference yield: 78.0%

ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate (1611461-94-9) + phenylboronic acid (98-80-6) → ethyl 5-([1,1'-biphenyl]-4-yl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate (1611462-22-6)

Guidance literature:

With potassium phosphate; dicyclohexyl(2,4,6-trimethoxyphenyl)phosphonium tetrafluoroborate; palladium diacetate; In 1,4-dioxane; water; at 110 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201310183

upstream raw materials:

4-chlorobenzaldehyde

ethyl 4-phenyl-2-(n-propyl)-2,3-butadienoate

Downstream raw materials:

(E)-1-(4-chlorophenyl)-4-(hydroxymethyl)-2-phenylhept-1-en-3-one

ethyl 5-([1,1'-biphenyl]-4-yl)-3-oxo-4-phenyl-2-propylpent-4(E)-enoate

(E)-ethyl 2-allyl-5-(4-chlorophenyl)-3-oxo-4-phenyl-2-propylpent-4-enoate

(E)-ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-(prop-2-ynyl)-2-propylpent-4-enoate