1611478-35-3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 107994-76-3 (E)-dimethyl(3-methylbut-1-en-1-yl)(phenyl)silane 
• 185990-03-8 dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane 
• 260975-32-4 (E)-4-methyl-N-(3-methylbutylidene)benzenesulfonamide 

Relevant academic research and scientific papers

Enantioselective synthesis of α-aminosilanes by copper-catalyzed hydroamination of vinylsilanes

The synthesis of α-aminosilanes by a highly enantio- and regioselective copper-catalyzed hydroamination of vinylsilanes is reported. The system employs Cu-DTBM-SEGPHOS as the catalyst, diethoxymethylsilane as the stoichiometric reductant, and O-benzoylhyd

Enantioselective addition of silicon nucleophiles to aldimines using a preformed NHC-copper(i) complex as the catalyst

A remaining major challenge in the asymmetric addition of silicon nucleophiles to typical prochiral acceptors, the enantioselective 1,2-addition to aldimines, is addressed. Activation of the Si-B bond in the silicon pronucleophile by a copper(I) alkoxide with McQuade's chiral six-membered N-heterocyclic carbene as a supporting ligand releases the silicon nucleophile, which adds to various aldimines with high levels of enantioselectivity. The new method provides a catalytic asymmetric access to α-silylated amines.