1611478-76-2

Upstream product

• 89-51-0 Homophthalic acid 
• 1611478-71-7 C₁₉H₂₂ClNO 
• 1611478-72-8 C₂₀H₂₄ClNO 
• 1611478-73-9 C₂₃H₂₂ClNO 
• 111060-49-2 N,N-dibenzyl-L-alanine benzyl ester 
• 111060-51-6 (S)-benzyl 2-(dibenzylamino)-3-methylbutanoate 
• 111060-50-5 (S)-benzyl 2-(dibenzylamino)-4-methylpentanoate 
• 111138-83-1 N,N-dibenzyl-L-phenylalanine benzyl ester 
• 93406-80-5 (S)-α-(N,N-dibenzylamino)propanoic acid 
• 94914-66-6 (S)-2-dibenzylamino-3-methylbutanoic acid 
• 95084-25-6 (S)-2-dibenzylamino-4-methylpentanoic acid 
• 95437-43-7 (S)-2-(N,N-dibenzylamino)-3-phenylpropanoic acid 

Relevant academic research and scientific papers

Chiral Pool-Based Synthesis of Naphtho-Fused Isocoumarins

A variety of chiral derivatives of benzo[d]naphtho[1,2-b]pyran-6-one were prepared in a single step by Et3N-mediated condensation of homophthalic anhydride with different derivatives of (S)-amino acid chlorides at -5 °C by employing a chiral pool methodology. Chirality 27:951-957, 2015.

Chiron based synthesis of isocoumarins: Reactivity of α-substituted carboxylic acids

The asymmetric synthesis of a novel (S)-isocoumarin has been attempted in a single step by the coupling of homophthalic acid with (S)-N-protected amino acids and α-chloroacids at high temperature by exploiting a chiral pool methodology. The coupling of homophthalic acid with N-protected (S)-amino acids gave exclusion of the carboxyl/alkyl group. However, coupling of homophthalic acid with α-chloroacids afforded asymmetric isocoumarins in high yield.