16116-87-3Relevant academic research and scientific papers
Fluoroform-Derived CuCF3 for Trifluoromethylation of Terminal and TMS-Protected Alkynes
He, Lisi,Tsui, Gavin Chit
supporting information, p. 2800 - 2803 (2016/07/06)
An efficient trifluoromethylation reaction of alkynes using a fluoroform-derived CuCF3 reagent is described. The CF3 source is the inexpensive industrial waste fluoroform (CF3H). The air-stable CuCF3 reagent can be prepared in large quantities and is convenient to use. Synthetically useful trifluoromethylated alkynes containing a wide range of functional groups were successfully synthesized under mild conditions. Both terminal and TMS-protected alkynes gave the products in one step. The beneficial effect of a diamine ligand tetramethylethylenediamine (TMEDA) with the fluoroform-derived CuCF3 reagent was also demonstrated.
PEST CONTROL AGENT
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Paragraph 0111, (2016/10/09)
PROBLEM TO BE SOLVED: To provide a compound having high activity to pest, a pest control agent obtained using the compound and a method for controlling pest by application of the compound. SOLUTION: The present invention provides the pest control agent co
Compounds 620
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Page/Page column 13, (2008/12/06)
This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
Dimetallation of phenylacetylene. Synthesis of ortho-susbtituted derivatives of phenylacetylene, benzoselenophene and benzotellurophene
Brandsma, L.,Hommes, H.,Verkruijsse, H. D.,Jong, R. L. P. de
, p. 226 - 230 (2007/10/02)
Phenylacetylene can be dimetallated in two ways. o-K-C6H4-CC-Li is formed by treating phenylacetylene at -70 deg C with two equivalents of butyllithium and one equivalent of potassium tert-butoxide in a mixture of tetrahydrofuran and hexane.The dimetallation with BuLi*N,N,N',N'-tetramethylethanediamine (TMEDA) affords a mixture of about 15percent (m + p)-Li-C6H4-CCLi and 85percent o-LiC6H4-CC-Li.Ortho-K-C6H4-CC-Li can be transformed into the dilithio or di-Grignard derivatives by addition of anhydrous lithium bromide or magnesium bromide etherate.Reaction of the dilithio derivative with elemental selenium and tellurium, followed by successive addition of tert-butyl alcohol and hexamethylphosphoric triamide (HMPT), gives benzoselenophene and benzotellurophene in good yields.Regiospecific functionalization of the nucleus via dimetal derivatives succeeds in the case of alkylation, halogenation, sulfenylation and acylation (with dimethylformamide and dimethylacetamide).Trimethylchlorosilane, chloromethyl methyl ether, aldehydes and ketones do not however react regiospecifically.
