161167-79-9

Upstream product

• 23382-09-4 silicon dioxide hydrate 
• 134896-35-8 2-phenyl-3-nitropyridine 
• 110529-27-6 (S)-1-[(2S)-1-benzylpyrrolidin-2-yl](phenyl)methanol 
• 1448990-99-5 (2R,3R)-1-benzyl-3-chloro-2-phenylpiperidine 
• 1448991-01-2 (2R,3R)-3-azido-1-benzyl-2-phenyl piperidine 
• 1448991-06-7 (2R,3R)-1-benzyl-2-phenylpiperidin-3-amine 

Downstream Products

• 815631-84-6 (2-(R)-phenyl-piperidin-3-(R)-yl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of versatile bifunctional derivatives of chiral diamines obtained through anchimerically assisted nucleophilic substitution reactions on diastereomeric phenylprolinols

Diastereomeric [(S)-1-benzylpyrrolidin-2-yl]-(R)-[(phenyl)- methanamine] and [(S)-1-benzylpyrrolidin-2-yl]-(S)-[(phenyl)methanamine], were synthesized by selective internal backside nucleophilic substitution of the corresponding activated phenylprolinols. X-Ray diffraction structures of crystalline acetamide derivatives confirmed the anticipated stereochemistry for a SNib reaction mechanism. In order to apply this reaction to the synthesis of bifunctional analogs, a series of fragments such as a thiourea moiety and sulfonamide functions were introduced for the functionalization of the primary amino group in the substrate, obtaining more stable and potentially useful derivatives.

Hemiaminals as substrates for sulfur ylides: Direct asymmetric syntheses of functionalised pyrrolidines and piperidines

Phenyl stabilised chiral sulfur ylides react with five-membered-ring hemiaminals to give functionalised pyrrolidines directly with high enantioselectivity. The reaction can be diverted to give piperidines instead by isolation of the intermediate epoxide and treatment with TMSOTf. The Royal Society of Chemistry 2006.

Method for producing optical-active cis-piperidine derivatives

An optical-active cis-piperidine derivative of high chemical purity and high optical purity is efficiently produced through optical resolution of a cis-piperidine derivative mixture, racemic cis-piperidine derivative with an optical-active tartaric acid d

F-18 radiolabeled neurokinin-1 receptor antagonists

The present invention is directed to radiolabeled neurokinin-1 receptor antagonists which are useful for the labeling and diagnostic imaging of neurokinin-1 receptors in mammals.

STEREOSELECTIVE PREPARATION OF SUBSTITUTED PIPERIDINES

Novel processes are disclosed for the stereoselective preparation of substituted piperidine derivatives of the formulae STR1 wherein R 1 and R 2 are defined as below, useful as substance P receptor antagonists and in treating diseases mediated by an exces