161170-64-5Relevant articles and documents
Asymmetric synthesis of methyl N-(1-phenylethyl)-3-aza-10-oxatricyclo[5.2.1.01,5]-4-oxo dec-8-en-6-carboxylate by an intramolecular Diels-Alder reaction
Zylber,Tubul,Brun
, p. 377 - 380 (1995)
The title compound can be obtained with up to five asymmetric centres of known absolute configuration by a diastereoselective intramolecular Diels-Alder reaction between optically active N-substituted furfurylamines and maleic anhydride, in which the chir
One-pot solvent-free reductive amination with a solid ammonium carbamate salt from CO2 and amine
Kang, Philjun,Lee, Kyu Myung,Lee, Won Koo,Lee, Kyu Hyung,Lee, Byeongno,Cho, Jaeheung,Hur, Nam Hwi
, p. 46203 - 46207 (2015/02/19)
Many amines are liquid and their handling is inconvenient compared with the corresponding solids. We transformed a liquid (S)-(-)-1-phenylethylamine 1 to the corresponding neutral solid form 2 by reacting with carbon dioxide. We performed reductive aminat
Scope of the organocatalysed asymmetric reductive amination of ketones with trichlorosilane
Gautier, Franois-Moana,Jones, Simon,Li, Xianfu,Martin, Stephen J.
experimental part, p. 7860 - 7868 (2011/12/02)
A highly active organocatalyst has been shown to affect the asymmetric reductive amination of ketones producing both aromatic and aliphatic amines. At 1 mol% catalyst loading, a series of structurally diverse chiral amines were quickly and economically prepared with good enantioselectivity and generally useful yield. The efficient synthesis of the calcimimetic (+)-NPS R-568 (67%, 89% ee) demonstrated the synthetic applicability of this methodology.