161190-55-2

Usage

Sulfoxide compound

Contains a sulfinyl group (S(=O)R2)

Used in pharmaceutical research and drug development

Potential applications in the development of new drugs

Chiral compound

Has a non-superposable mirror image

Stereochemistry

The "S" in brackets indicates the configuration of the chiral center

Contains a 1H-imidazol-2-yl group

A five-membered ring system with a nitrogen atom at the 1-position

Contains a 2-methylphenyl group

A phenyl ring with a methyl group at the 2-position

Potential biological activities

May interact with biological systems in a stereospecific manner

Further research needed

To fully understand the properties and potential applications of this chemical compound.

Upstream product

• 25372-14-9 N-(2-methylphenyl)-2-mercaptoimidazole 
• 614-69-7 2-tolyl isothiocyanate 
• 161190-54-1 3-(1-o-tolyl-1H-imidazol-2-ylsulfanyl)propan-1-ol 
• 200805-75-0 (S)-(+)-3-[1-(2-methylphenyl)2-imidazolylsulfinyl]propanol 

Relevant academic research and scientific papers

Catalytic asymmetric oxidation of sulfide with titanium-mandelic acid complex: Practical synthesis of (S)-3-[1-(2-methylphenyl)imidazol-2-ylsulfinyl]propan-1-ol, the key intermediate of OPC-29030

An effective catalytic asymmetric oxidation of prochiral sulfide 1a to (S)-2a has been achieved by the use of chiral titanium-mandelic acid complex. The enantioselectivity was found to be not influenced by moisture, and moderate to high selectivity (76% e

Synthesis of a key intermediate, (S)-2-[(3-hydroxypropyl)sulfinyl]-1-(o-tolyl)imidazole, for the platelet aggregation inhibitor, OPC-29030 via lipase-catalyzed enantioselective transesterification

Optically active 2-[(3-hydroxypropyl)sulfinyl]-1-(o-tolyl)imidazole (S)-2 was synthesized by kinetic resolution of (±)-2 with lipase and hydrolysis of the acetate (S)-3 with potassium carbonate. The reaction mixture of the lipase-catalyzed transesterifica