25372-14-9

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL is used as a chelating ligand in the pharmaceutical industry for its ability to form stable complexes with metal ions, which can be crucial in the development of new drugs with enhanced properties and targeted action.
Used in Agrochemical Development:
In the agrochemical industry, 1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL is utilized as a key intermediate in the synthesis of various agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Medicinal Chemistry Research:
1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL is employed as a subject of interest in medicinal chemistry research due to its potential biological activity. Its unique structure allows for exploration in the development of novel therapeutic agents and understanding its interactions with biological targets.

InChI:InChI=1/C10H10N2S/c1-8-4-2-3-5-9(8)12-7-6-11-10(12)13/h2-7H,1H3,(H,11,13)

Upstream product

• 60185-84-4 3-aminopropionaldehyde dimethyl acetal 
• 614-69-7 2-tolyl isothiocyanate 
• 3129-90-6 isothiocyanic acid 

Downstream Products

• 113857-31-1 3,4-dihydro-6-<3-(1-o-tolyl-2-imidazolyl)thiopropoxy>-2(1H)-quinolinone 
• 173416-61-0 (R)-(+)-3,4-dihydro-6-<2-hydroxy-3-(1-o-tolyl-2-imidazolyl)thiopropoxy>-2(1H)-quinolinone 
• 161190-54-1 3-(1-o-tolyl-1H-imidazol-2-ylsulfanyl)propan-1-ol 
• 116072-39-0 2-methylthio-1-o-tolyl-1H-imidazole 
• 161190-39-2 (+/-)-3,4-dihydro-6-<3-(1-o-tolyl-2-imidazolyl)sulfinylpropoxy>-2(1H)-quinolinone 
• 161190-55-2 (S)-3-(1-o-tolyl-1H-imidazol-2-ylsulfanyl)propan-1-ol 

Relevant academic research and scientific papers

New bis(mercaptoimidazolyl)(pyrazolyl)borate ligands and their zinc complex chemistry

Nine new tripodal NS2 ligands of the bis(mercaptoimidazolyl)(pyrazolyl)borate type with varying 3-R-mercaptoimidazolyl moieties were prepared as their potassium salts. Treatment with zinc salts yielded the complex types L·Zn-Cl, L·Zn-I, L·Zn-ONO2, L·Zn-OClO3 and [L·Zn(imidazole)]ClO4. Attempts at the formation of L·Zn-OH or cationic L·Zn complexes resulted in dismutation and formation of ZnL2 complexes. Hydrolytic destruction yielded one [OZn4(thiooimidazolate)6] complex. The ZnS2NO coordination which is present in the enzyme-substrate complex of alcohol dehydrogenase could be successfully modelled by an [L·Zn(C2H5OH)]+ complex. The L·Zn-X complexes showed very low catalytic activity in the dehydrogenation of 2-propanol or the hydrogenation of p-nitrobenzaldehyde. The new compounds were identified by a total of 12 structure determinations. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Catalytic asymmetric oxidation of sulfide with titanium-mandelic acid complex: Practical synthesis of (S)-3-[1-(2-methylphenyl)imidazol-2-ylsulfinyl]propan-1-ol, the key intermediate of OPC-29030

An effective catalytic asymmetric oxidation of prochiral sulfide 1a to (S)-2a has been achieved by the use of chiral titanium-mandelic acid complex. The enantioselectivity was found to be not influenced by moisture, and moderate to high selectivity (76% e