161196-61-8Relevant articles and documents
Syntheses of conformationally restricted analogues of an angiotensin II receptor antagonist. General synthetic approach to functionalized imidazo[1,5-a]pyridine derivatives
Musicki, Branislav,Vevert, Jean-Paul
, p. 9391 - 9394 (2007/10/02)
Syntheses of two conformationally restricted analogues 3 and 4 of the angiotensin II receptor antagonists losartan (1) are described. Michael addition of imidazole-5-carboxaldehyde 8 to biphenylpropiolate 7 provides an efficient method for the skeletal construction of imidazo[1,5-α]pyridine derivatives.