Welcome to LookChem.com Sign In|Join Free
  • or
5-(3-fluoro-phenyl)-3-phenyl-4,5-dihydro-1H-pyrazole is a complex organic compound with the molecular formula C15H12FN2. It features a pyrazole ring, which is a five-membered aromatic heterocyclic compound containing three carbon atoms and two nitrogen atoms. The structure is further characterized by a 3-fluoro-phenyl group attached to the 5-position of the pyrazole ring and a phenyl group at the 3-position. 5-(3-fluoro-phenyl)-3-phenyl-4,5-dihydro-1H-pyrazole is a derivative of pyrazole and is part of a class of compounds known for their potential applications in pharmaceuticals and materials science. The presence of the fluorine atom in the 3-fluoro-phenyl group introduces unique electronic and steric properties, which can significantly affect the compound's reactivity and interactions with other molecules.

1612-04-0

Post Buying Request

1612-04-0 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1612-04-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1612-04-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,1 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1612-04:
(6*1)+(5*6)+(4*1)+(3*2)+(2*0)+(1*4)=50
50 % 10 = 0
So 1612-04-0 is a valid CAS Registry Number.

1612-04-0Relevant academic research and scientific papers

Design, modification and 3D QSAR studies of novel 2,3-dihydrobenzo[b][1,4] dioxin-containing 4,5-dihydro-1H-pyrazole derivatives as inhibitors of B-Raf kinase

Yang, Yu-Shun,Li, Qing-Shan,Sun, Shuai,Zhang, Yan-Bin,Wang, Xiao-Liang,Zhang, Fei,Tang, Jian-Feng,Zhu, Hai-Liang

, p. 6048 - 6058 (2012/11/07)

Two series of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives C1-C15 and D1-D15 have been synthesized and evaluated for their B-Raf inhibitory and anti-proliferation activities. Compound C14 ((3-(4-bromophenyl)-5-(2-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2,3- dihydrobenzo[b][1,4]dioxin-6-yl)methanone) showed the most potent biological activity against B-RafV600E (IC50 = 0.11 μM) and WM266.4 human melanoma cell line (GI50 = 0.58 μM), being comparable with the positive control Erlotinib and more potent than our previous best compound, while D10 ((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(5-(3- fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone) performed the best in the D series (IC50 = 1.70 μM; GI50 = 1.45 μM). The docking simulation was performed to analyze the probable binding models and poses and the QSAR model was built for reasonable design of B-Raf inhibitors in future. The introduction of 2,3-dihydrobenzo[b][1,4]dioxin structure reinforced the combination of our compounds and the receptor, resulting in progress of bioactivity.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 1612-04-0