1612143-65-3

Basic information

• Product Name: tert-butyl ((1S,2R)-2-(4-chlorophenyl)cyclopropyl)carbamate
• CAS NO: 1612143-65-3
• Molecular Weight: 267.755
• Mol File: 1612143-65-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl ((1S,2R)-2-(4-chlorophenyl)cyclopropyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((1S,2R)-2-(4-chlorophenyl)cyclopropyl)carbamate(1612143-65-3)
• EPA Substance Registry System: tert-butyl ((1S,2R)-2-(4-chlorophenyl)cyclopropyl)carbamate(1612143-65-3)

Safety Data

• Hazardous Substances Data: 1612143-65-3(Hazardous Substances Data)

Upstream product

• 35086-79-4 cinnamoyl chloride 
• 1612143-64-2 ((1S,2S)-2-(4-chlorophenyl)cyclopropyl)((3aR,6S,7aS)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)methanone 
• 1092682-58-0 (E)-3-(4-chlorophenyl)-1-((3aR,6S,7aS)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one 
• 142793-24-6 (+)-(1S,2S)-2-(4-chlorophenyl)cyclopropanecarboxylic acid 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1612143-70-0 (1S,2R)-2-(4-chlorophenyl)-N-propylcyclopropan-1-amine 
• 209738-24-9 (1S,2R)-2-(4-chlorophenyl)cyclopropan-1-amine 
• 1612143-75-5 N-(cis-3-(2-(((1S,2R)-2-(4-chlorophenyl)cyclopropyl)(propyl)amino)ethyl)-3-hydroxycyclobutyl)-2-naphthamide 

Relevant articles and documents

Tranylcypromine substituted cis -hydroxycyclobutylnaphthamides as potent and selective dopamine D3 receptor antagonists

We report a class of potent and selective dopamine D3 receptor antagonists based upon tranylcypromine. Although tranylcypromine has a low affinity for the rat D3 receptor (Ki = 12.8 μM), our efforts have yielded (1R,2S)-11 (CJ-1882), which has Ki values of 2.7 and 2.8 nM at the rat and human dopamine D3 receptors, respectively, and displays respective selectivities of >10000-fold and 223-fold over the rat and human D2 receptors. Evaluation in a β-arrestin functional assay showed that (1R,2S)-11 is a potent and competitive antagonist at the human D3 receptor.