1612232-97-9

Upstream product

• 1654738-11-0 (2S)-1-(4-formylphenyl)sulfonylpyrrolidine-2-carboxylic acid 
• 348-54-9 2-Fluoroaniline 
• 1612232-96-8 [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] (2S)-1-(4-formylphenyl)sulfonylpyrrolidine-2-carboxylate 
• 85822-16-8 4-formylbenzene-1-sulfonyl chloride 
• 2812-46-6 proline tert-butyl ester 

Downstream Products

• 1612232-71-9 [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl](2S)-1-[4-[(2-fluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]phenyl]sulfonylpyrrolidine-2-carboxylate 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

Compounds of formula (I) described herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS

The invention relates to novel compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.