85822-16-8

Basic information

• Product Name: 4-FORMYLBENZENESULFONYL CHLORIDE
• Synonyms: 4-FORMYLBENZENESULFONYL CHLORIDE;Benzenesulfonyl chloride, 4-formyl- (9CI);Benzenesulfonyl chloride, 4-formyl-;4-Formylbenzene-1-sulfonyl chloride
• CAS NO: 85822-16-8
• Molecular Formula: C₇H₅ClO₃S
• Molecular Weight: 204.63
• Product Categories: SULFONYLHALIDE
• Mol File: 85822-16-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 327 °C at 760 mmHg
• Flash Point: 151.6 °C
• Appearance: /
• Density: 1.485 g/cm³
• Vapor Pressure: 0.000208mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-FORMYLBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FORMYLBENZENESULFONYL CHLORIDE(85822-16-8)
• EPA Substance Registry System: 4-FORMYLBENZENESULFONYL CHLORIDE(85822-16-8)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• Hazardous Substances Data: 85822-16-8(Hazardous Substances Data)

Usage

General Description

4-Formylbenzenesulfonyl chloride is a chemical compound with the molecular formula C7H5ClO2S. It is a sulfonyl chloride derivative that is commonly used as a reagent in organic synthesis, particularly in the conversion of carboxylic acids to their corresponding acid chlorides. 4-FORMYLBENZENESULFONYL CHLORIDE is a highly reactive and versatile reagent, and it is also used in the production of pharmaceuticals and agrochemicals. It is a white solid that is soluble in organic solvents such as dichloromethane and tetrahydrofuran, and its reactivity and versatility make it a valuable tool in the field of organic chemistry.

InChI:InChI=1/C7H5ClO3S/c8-12(10,11)7-3-1-6(5-9)2-4-7/h1-5H

Upstream product

• 91358-96-2 4-mercaptobenzaldehyde 
• 127-65-1 chloroamine-T 
• 13736-22-6 sodium 4-carboxy-benzenesulfonate 

Downstream Products

• 106939-94-0 (p-methoxyphenyl) 2-formylbenzenesulfonate 
• 1057490-85-3 4-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)benzaldehyde 
• 780777-94-8 4-(1,3-dihydro-isoindole-2-sulfonyl)-benzaldehyde 
• 3218-36-8 4-Phenylbenzaldehyde 
• 816450-54-1 N-(4-chlorophenyl)-4-formylbenzenesulfonamide 

Relevant articles and documents

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB—Utilizing a Reversible Covalent Tethering Approach

Protein-protein modulation has emerged as a proven approach to drug discovery. While significant progress has been gained in developing protein-protein interaction (PPI) inhibitors, the orthogonal approach of PPI stabilization lacks established methodologies for drug design. Here, we report the systematic ″bottom-up″ development of a reversible covalent PPI stabilizer. An imine bond was employed to anchor the stabilizer at the interface of the 14-3-3/p65 complex, leading to a molecular glue that elicited an 81-fold increase in complex stabilization. Utilizing protein crystallography and biophysical assays, we deconvoluted how chemical properties of a stabilizer translate to structural changes in the ternary 14-3-3/p65/molecular glue complex. Furthermore, we explore how this leads to high cooperativity and increased stability of the complex.

Aminoxidation of Arenethiols to N-Chloro-N-sulfonyl Sulfinamides

A simple and efficient method to synthesize N-chloro-N-sulfonylsulfinamides by the direct aminoxidation of arenethiols under aqueous and mild conditions is disclosed, geminally installing the oxo and amino groups on the sulfur atom of arenethiols. The products have been primarily developed as sulfinylation reagents to convert Grignard reagents into sulfoxides, and as amination reagents to convert secondary amines into hydrazine derivatives.