85822-16-8

Usage

Uses

Used in Organic Synthesis:
4-Formylbenzenesulfonyl chloride is used as a reagent for converting carboxylic acids to their corresponding acid chlorides, which is a critical step in various organic synthesis processes. Its high reactivity allows for efficient transformations, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-Formylbenzenesulfonyl chloride is utilized as a key intermediate in the synthesis of various drug molecules. Its ability to facilitate the formation of acid chlorides from carboxylic acids is essential for the creation of active pharmaceutical ingredients, contributing to the development of new medications.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 4-Formylbenzenesulfonyl chloride is employed in the synthesis of compounds used in pesticides and other agricultural chemicals. Its role in organic synthesis aids in the production of effective and targeted agrochemicals, enhancing crop protection and yield.
Used in Research and Development:
4-Formylbenzenesulfonyl chloride is also used as a research tool in academic and industrial laboratories. Its versatility in organic synthesis makes it a preferred reagent for exploring new chemical reactions and developing innovative synthetic pathways, further expanding the horizons of chemical research.

InChI:InChI=1/C7H5ClO3S/c8-12(10,11)7-3-1-6(5-9)2-4-7/h1-5H

Upstream product

• 13736-22-6 sodium 4-carboxy-benzenesulfonate 
• 91358-96-2 4-mercaptobenzaldehyde 
• 127-65-1 chloroamine-T 

Downstream Products

• 106939-94-0 (p-methoxyphenyl) 2-formylbenzenesulfonate 
• 816450-54-1 N-(4-chlorophenyl)-4-formylbenzenesulfonamide 
• 179057-22-8 4-formyl-N-phenylbenzenesulfonamide 
• 881377-22-6 N-{2-tertbutyl-1-[(4,4-difluorocyclohexyl)-methyl]-1H-benzimidazol-5-yl}-4-formyl-N-methylbenzenesulfonamide 
• 920536-28-3 4-formyl-N-(4-trifluoromethoxy-phenyl)-benzenesulfonamide 
• 933683-83-1 C₁₀H₈N₂O₃S₂ 
• 1057490-85-3 4-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)benzaldehyde 
• 780777-94-8 4-(1,3-dihydro-isoindole-2-sulfonyl)-benzaldehyde 
• 937074-18-5 2,2'-[{[(4-formylphenyl)sulfonyl]imino}bis(methylene)]bis(N,N-dimethyl-1H-imidazole-1-sulfonamide) 
• 195155-27-2 4-[(4-methylpiperazin-1-yl)sulfonyl]benzaldehyde 
• 1080675-49-5 4-[(4-hydroxypiperidin-1-yl)sulfonyl]benzaldehyde 
• 1070870-97-1 methyl (4-(6-fluoro-3'-methyl-2-biphenylyl)-4-{(3R)-1-[(4-formylphenyl)sulfonyl]-3-piperidinyl}-4-hydroxybutyl)carbamate 
• 1080675-44-0 4-formyl-N-(2-hydroxy-2-methylpropyl)-benzene sulfonamide 
• 1186230-59-0 pentafluorophenyl 4-formylbenzenesulfonate 

Relevant academic research and scientific papers

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB—Utilizing a Reversible Covalent Tethering Approach

Protein-protein modulation has emerged as a proven approach to drug discovery. While significant progress has been gained in developing protein-protein interaction (PPI) inhibitors, the orthogonal approach of PPI stabilization lacks established methodologies for drug design. Here, we report the systematic ″bottom-up″ development of a reversible covalent PPI stabilizer. An imine bond was employed to anchor the stabilizer at the interface of the 14-3-3/p65 complex, leading to a molecular glue that elicited an 81-fold increase in complex stabilization. Utilizing protein crystallography and biophysical assays, we deconvoluted how chemical properties of a stabilizer translate to structural changes in the ternary 14-3-3/p65/molecular glue complex. Furthermore, we explore how this leads to high cooperativity and increased stability of the complex.

PROTEIN-PROTEIN INTERACTION STABILIZERS

Provided herein, inter alia, are stabilizers of protein-protein interactions and methods of identifying and using the same.

Aminoxidation of Arenethiols to N-Chloro-N-sulfonyl Sulfinamides

A simple and efficient method to synthesize N-chloro-N-sulfonylsulfinamides by the direct aminoxidation of arenethiols under aqueous and mild conditions is disclosed, geminally installing the oxo and amino groups on the sulfur atom of arenethiols. The products have been primarily developed as sulfinylation reagents to convert Grignard reagents into sulfoxides, and as amination reagents to convert secondary amines into hydrazine derivatives.

2-Substituted and 4-substituted aryl nitrone compounds

The present invention provides aryl nitrones, compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine mediated conditions.