1612263-32-7

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 24395-14-0 (R)-2-phenyl-N-tosylaziridine 
• 597572-25-3 (R)-1-methyl-4-(2-nitro-1-phenylethyl)benzene 
• 98-80-6 phenylboronic acid 
• 7559-36-6 4-methyl-β-nitrostyrene 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant academic research and scientific papers

Asymmetric synthesis via stereospecific C-N and C-O bond activation of alkyl amine and alcohol derivatives

This perspective showcases our development of benzylic and allylic amine and alcohol derivatives as electrophiles for stereospecific, nickel-catalyzed cross-coupling reactions, as well as the prior art that inspired our efforts. The success of our effort

Pd/NHC-catalyzed enantiospecific and regioselective suzuki-miyaura arylation of 2-arylaziridines: Synthesis of enantioenriched 2-arylphenethylamine derivatives

A palladium-catalyzed stereospecific and regioselective cross-coupling of enantiopure 2-arylaziridines with arylboronic acids under mild conditions to construct a tertiary stereogenic center has been developed. N-heterocyclic carbene (NHC) ligands efficiently promote the coupling, suppressing β-hydride elimination. The enantiospecific cross-coupling allowed us for preparation of a series of biologically important 2-arylphenethylamine derivatives in an enantiopure form.