16125-72-7Relevant academic research and scientific papers
Dihydrazone compound high in affinity with Abeta protein and Tau protein, derivative thereof, and applications of dihydrazone compound and derivative
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Paragraph 0080-0082; 0110-0112, (2019/05/15)
The invention provides a dihydrazone compound high in affinity with Abeta protein and Tau protein, a derivative thereof, and applications of the dihydrazone compound and the derivative. The structureof the dihydrazone compound is represented by formula I. The dihydrazone compound can be directly taken as a fluorescence probe used for detecting neurofibrillary tangles in vivo or in tissue samples;when the dihydrazone compound is adopted in nuclear medicine imaging, appropriate radioisotopes are needed for labeling. The dihydrazone compound is especially suitable to be used for diagnosis of neurodegenerative diseases, and diagnosis of patients with diseases with Abeta plaques including Alzheimer's disease.
Compound capable of detecting organophosphate neurotoxic agent stimulants and application thereof
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Paragraph 0034; 0035; 0036; 0037; 0038, (2017/03/08)
The invention relates to a compound capable of detecting an organophosphate neurotoxic agent stimulants and application thereof. The compound has a structural general formula shown as the specification, can be used for detection of organophosphate neurotoxic agent stimulants according to the change of color or fluorescence in preparation of solutions, films or test paper. The compound provided by the invention has the advantages of simple preparation method, high yield, easy separation, high purity, and sensitive response to organophosphorus neurotoxic agents, and can achieve quick and accurate detection of organophosphorus neurotoxic agent stimulants in solutions or gas phases.
