161258-41-9

Basic information

• Product Name: N-Benzyl 3-bromobenzamide
• Synonyms: Benzamide, 3-bromo-N-(phenylmethyl)-
• CAS NO: 161258-41-9
• Molecular Formula: C14H12BrNO
• Molecular Weight: 290.16
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 161258-41-9.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Benzyl 3-bromobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl 3-bromobenzamide(161258-41-9)
• EPA Substance Registry System: N-Benzyl 3-bromobenzamide(161258-41-9)

Safety Data

• Hazardous Substances Data: 161258-41-9(Hazardous Substances Data)

Usage

General Description

N-Benzyl 3-bromobenzamide is a chemical compound consisting of a benzyl group attached to a 3-bromobenzamide molecule. It is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. The benzyl group provides stability and reactivity, while the 3-bromobenzamide moiety offers opportunities for further functionalization. N-Benzyl 3-bromobenzamide has applications in drug discovery and development due to its potential as a pharmacophore or chemical scaffold for designing new therapeutic agents. Additionally, it may be utilized in the preparation of advanced materials and specialty chemicals. However, it is important to handle N-Benzyl 3-bromobenzamide with caution, as it may have hazardous properties and should be used in a controlled laboratory environment.

Upstream product

• 538-86-3 benzyl methyl ether 
• 6952-59-6 3-cyanobromobenzene 
• 585-76-2 m-bromobenzoic acid 
• 100-46-9 benzylamine 
• 140-11-4 Benzyl acetate 
• 100-44-7 benzyl chloride 
• 3132-99-8 m-bromobenzoic aldehyde 
• 22726-00-7 3-bromobenzamide 
• 100-51-6 benzyl alcohol 
• 1711-09-7 3-bromobenzoyl chloride 

Relevant articles and documents

Amidation of Aldehydes with Amines under Mild Conditions Using Metal-Organic Framework Derived NiO@Ni Mott-Schottky Catalyst

Here we report a facile method for the synthesis of nickel oxide-nickel (NiO@Ni) Mott-Schottky catalyst employing metal-organic framework (MOF) as the precursor. A direct amidation protocol of aldehydes with amines has been optimized under mild conditions using NiO@Ni Mott-Schottky catalyst and it shows far better catalytic activity than the NiO?Ni nanoparticles prepared from simple Ni2+ salt under similar reaction conditions. The heterogeneous catalyst is robust, recyclable and efficient to provide comparable yield to costly ligand-based homogeneous Ni catalysts. The scope of the reaction protocol has been explored with variably substituted substrates. The reaction initiates by homolytic cleavage of peroxide and proceeds through radical mechanism.

Hydrogen Bond Directed ortho-Selective C?H Borylation of Secondary Aromatic Amides

Reported is an iridium catalyst for ortho-selective C?H borylation of challenging secondary aromatic amide substrates, and the regioselectivity is controlled by hydrogen-bond interactions. The BAIPy-Ir catalyst forms three hydrogen bonds with the substrate during the crucial activation step, and allows ortho-C?H borylation with high selectivity. The catalyst displays unprecedented ortho selectivities for a wide variety of substrates that differ in electronic and steric properties, and the catalyst tolerates various functional groups. The regioselective C?H borylation catalyst is readily accessible and converts substrates on gram scale with high selectivity and conversion.

FeCl2·4H2O catalyzed ritter reaction with nitriles and halohydrocarbons

An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with various halohydrocarbons catalyzed by FeCl2·4H2O is described. FeCl2·4H2O economically efficiently catalyzed the Ritter reaction under solvent-free conditions. A range of halohydrocarbons (benzyl, tert-butyl and sec-alkyl halohydrocarbons) were coupled with nitriles to provide the corresponding amides in high to excellent yields.