161264-89-7

Basic information

• Product Name: 2-[1,1'-BIPHENYL]-4-YL-4-METHYL-2-MORPHOLINOL
• Synonyms: 2-[1,1'-BIPHENYL]-4-YL-4-METHYL-2-MORPHOLINOL
• CAS NO: 161264-89-7
• Molecular Formula: C₁₇H₁₉NO₂
• Molecular Weight: 269.342
• Mol File: 161264-89-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[1,1'-BIPHENYL]-4-YL-4-METHYL-2-MORPHOLINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1,1'-BIPHENYL]-4-YL-4-METHYL-2-MORPHOLINOL(161264-89-7)
• EPA Substance Registry System: 2-[1,1'-BIPHENYL]-4-YL-4-METHYL-2-MORPHOLINOL(161264-89-7)

Safety Data

• Hazardous Substances Data: 161264-89-7(Hazardous Substances Data)

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 135-73-9 2-Bromo-4'-phenylacetophenone 

Relevant articles and documents

Hypocholesterolemic and hypolipidemic activity of some novel morpholine derivatives with antioxidant activity

In this investigation, we study the synthesis and the evaluation of antioxidant and hypocholesterolemic activity of a number of 2-biphenylyl morpholine derivatives, which are structurally similar to some substituted morpholines possessing antioxidant activity, as well as to hypocholesterolemic 3-biaryl-quinuclidines. The novel derivatives are found to inhibit the ferrous/ascorbate induced lipid peroxidation of microsomal membrane lipids, the most potent derivative, 2-(4-biphenyl)-4-methyl- octahydro-1,4-benzoxazin-2-ol (compound 7), having an IC50 value of 250 μM. In addition, these compounds demonstrate hypocholesterolemic and hypolipidemic action. The most active compound (7) decreases total cholesterol, low density lipoprotein, and triglycerides in plasma of Triton WR-1339 induced hyperlipidemic rats by 54%, 51%, and 49%, respectively, at 28 μmol/kg (ip). The above results indicate that the new molecules may be proven useful as leads for the design of novel compounds as potentially antiatherogenic factors.