1612760-02-7

Basic information

• Product Name: 1-(4-iodophenyl)ethanone O-acetyl oxime
• Synonyms: 1-(4-iodophenyl)ethanone O-acetyl oxime
• CAS NO: 1612760-02-7
• Molecular Weight: 303.099
• Mol File: 1612760-02-7.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-iodophenyl)ethanone O-acetyl oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-iodophenyl)ethanone O-acetyl oxime(1612760-02-7)
• EPA Substance Registry System: 1-(4-iodophenyl)ethanone O-acetyl oxime(1612760-02-7)

Safety Data

• Hazardous Substances Data: 1612760-02-7(Hazardous Substances Data)

Upstream product

• 27760-43-6 1-(4-iodophenyl)ethan-1-one oxime 
• 108-24-7 acetic anhydride 
• 13329-40-3 4-Iodoacetophenone 

Downstream Products

• 214958-27-7 2-(4-iodophenyl)imidazo[1,2-α]pyridine 
• 1426022-12-9 2-(4-iodophenyl)-4-phenylpyridine 

Relevant articles and documents

Copper(0)/PPh3-Mediated Bisheteroannulations of o-Nitroalkynes with Methylketoximes Accessing Pyrazo-Fused Pseudoindoxyls

A copper(0)/PPh3-mediated cascade bisheteroannulation reaction of o-nitroalkynes with methylketoximes has been developed that provides viable access to a diverse range of pyrazo-fused pseudoindoxyl compounds. Synthetically useful functional groups including sensitive C-I bonds are compatible with this system. Mechanistic studies suggest a reaction cascade involving sequential PPh3-mediated deoxygenative cycloisomerization and copper-catalyzed [3 + 2] pyrazo-annulation.

Direct access to bis-S-heterocycles via copper-catalyzed three component tandem cyclization using S8 as a sulfur source

A novel strategy for constructing sulfur containing bis-S-heterocyclic compounds from oxime esters/vinyl azide, phenylacetylene/aldehydes and elemental sulfur (S8) has been developed. These transformations show good functional group tolerance. Various bis-S-heterocyclic products were efficiently synthesized from easily prepared or widely commercially available starting materials. In this protocol, S8 successfully served as a two-sulfur atom donor for thiophene and thiazole rings, respectively.

Copper-catalyzed synthesis of thiazol-2-yl ethers from oxime acetates and xanthates under redox-neutral conditions

A novel copper-catalyzed annulation of oxime acetates and xanthates for the synthesis of thiazol-2-yl ethers with remarkable regioselectivity has been developed. Various oxime acetates, whether derived from aryl ketones or alkyl ketones, or natural product cores are suitable for this conversion. Unique dihydrothiazoles were also obtained when both reaction sites were methine. Mechanistic studies indicated that imino copper(iii) intermediates were involved. In addition, this protocol proceeded under redox-neutral conditions and did not require additives or ligands.