1612776-80-3Relevant academic research and scientific papers
Expansion of antibacterial spectrum of muraymycins toward pseudomonas aeruginosa
Takeoka, Yusuke,Tanino, Tetsuya,Sekiguchi, Mitsuaki,Yonezawa, Shuji,Sakagami, Masahiro,Takahashi, Fumiyo,Togame, Hiroko,Tanaka, Yoshikazu,Takemoto, Hiroshi,Ichikawa, Satoshi,Matsuda, Akira
supporting information, p. 556 - 560 (2014/06/09)
It is urgent to develop novel anti-Pseudomonas agents that should also be active against multidrug resistant P. aeruginosa. Expanding the antibacterial spectrum of muraymycins toward P. aeruginosa was investigated by the systematic structure-activity relationship study. It was revealed that two functional groups, a lipophilic side chain and a guanidino group, at the accessory moiety of muraymycins were important for the anti-Pseudomonas activity, and analogue 29 exhibited antibacterial activity against a range of P. aeruginosa strains with the minimum inhibitory concentration values of 4-8 μg/mL.
