1612790-52-9Relevant academic research and scientific papers
A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides: Direct access to 1,4,5-trisubstituted 1,2,3-triazoles
Yuan, Huijun,Zhang, Lili,Liu, Zhantao,Liu, Yang,Wang, Jian,Li, Wenjun
supporting information, p. 4286 - 4290 (2017/07/10)
A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides has been developed. This strategy could generate 1,4,5-trisubstituted 1,2,3-triazoles in high yields and regioselectivities in the presence of a 20 mol% N-heterocyclic carbene catalyst. A broad substrate scope of this process is also presented.
Method for synthesizing 1,4,5-trisubstituted-1,2,3-triazole compound
-
Paragraph 0065; 0066; 0067, (2017/08/31)
The invention discloses a method for synthesizing a 1,4,5-trisubstituted-1,2,3-triazole compound under catalysis of carbine. The 1,4,5-trisubstituted-1,2,3-triazole compound is prepared by allowing allyl ketone and nitrine which are reacting raw materials to react in a reaction solvent in the presence of a catalyst which is carbine. The method has the advantages of mild reaction condition, easily available and low-price raw material, simple reacting operation and relatively high yield, provides a key frame structure for various natural product and medicine synthesis, and can be widely applied to industrial large-scale production.
Direct access to 1,2,3-triazoles through organocatalytic 1,3-dipolar cycloaddition reaction of allyl ketones with azides
Li, Wenjun,Du, Zhiyun,Huang, Jiayao,Jia, Qianfa,Zhang, Kun,Wang, Jian
, p. 3003 - 3006 (2014/06/10)
A general organocatalytic 1,3-dipolar cycloaddition reaction between allyl ketones and various azides is reported. The reaction is catalyzed by a secondary amine to generate substituted 1,2,3-triazoles with high levels of regioselectivity. This journal is the Partner Organisations 2014.
