1612853-73-2

Upstream product

• 1418128-76-3 acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl ester 
• 1612853-65-2 5-bromo-3-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-1H-pyridin-2-one 
• 1242156-63-3 (5-bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-[5-(morpholine-4-carbonyl)pyridin-2-yl]carbamic acid tert-butyl ester 
• 1147530-81-1 5-bromo-1-methyl-3-((5-(morpholine-4-carbonyl)pyridin-2-yl)amino)pyridine-2(1H)-one 
• 1242156-64-4 (5-bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-(5-formylpyridin-2-yl)carbamic acid tert-butyl ester 
• 1612853-63-0 (5-bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-{5-[(2-methoxyethylamino)methyl]pyridin-2-yl}carbamic acid tert-butyl ester 
• 1612853-69-6 2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde 
• 1178884-68-8 6-(tert-butyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 64622-16-8 2-bromo-6-chlorobenzaldehyde 
• 1462328-88-6 6-tert-butyl-2-(3-chloro-2-hydroxymethylphenyl)-3,4-dihydro-2H-isoquinolin-1-one 
• 1612853-72-1 acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester 

Downstream Products

• 1612853-22-1 6-tert-butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxyethylamino)methyl]pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one 

Relevant academic research and scientific papers

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses the Btk inhibitor compounds 6-tert-Butyl-8-fluoro-2-{3- hydroxymethyl-4-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-6-ylamino)- 6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1- ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2- hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile, and 6-tert-Butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxy-ethylamino)-methyl]-pyridin-2- ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, formulations thereof, and methods of treatment of asthma, as described herein.