1612877-74-3

Basic information

• Product Name: (E)-1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
• Synonyms: (E)-1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
• CAS NO: 1612877-74-3
• Molecular Weight: 352.43
• Mol File: 1612877-74-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one(1612877-74-3)
• EPA Substance Registry System: (E)-1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one(1612877-74-3)

Safety Data

• Hazardous Substances Data: 1612877-74-3(Hazardous Substances Data)

Upstream product

• 1612877-82-3 1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)ethanone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 699-83-2 2,6-dihydroxylacetophenone 
• 18928-94-4 (2-bromo-ethyl)-cyclopentane 

Relevant articles and documents

Anti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells

To investigate the anti-proliferative effect of NF-κB inhibitor, a series of analogs of (E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4- hydroxyphenyl)prop-2-en-1-one (5a) were prepared and evaluated for their NF-κB inhibition and anti-proliferative activity against various human cancer cell lines. Compounds (E)-1-(2-(3,3-dimethylbutoxy)-6-hydroxyphenyl)-3- (4-hydroxyphenyl)prop-2-en-1-one (5e) and (E)-4-(3-(2-(3,3-dimethylbutoxy)-6- hydroxyphenyl)-3-oxoprop-1-enyl)benzenesulfonamide (5p) showed good NF-κB inhibition as well as potent anti-proliferative activity. SAR studies showed that all the compounds with potent or moderate NF-κB inhibition displayed good anti-proliferative activity. All the analogs (5b-r) maintained a good correlation between their NF-κB inhibition and anti-proliferative activity though the extent is not directly proportional to each other.