18928-94-4

Basic information

• Product Name: β-cyclopentylethyl bromide
• Synonyms: β-cyclopentylethyl bromide;(2-BroMoethyl)cyclopentane
• CAS NO: 18928-94-4
• Molecular Formula: C₇H₁₃Br
• Molecular Weight: 177.08212
• Mol File: 18928-94-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 177.131°C at 760 mmHg
• Flash Point: 68.49°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 1.422mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: β-cyclopentylethyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: β-cyclopentylethyl bromide(18928-94-4)
• EPA Substance Registry System: β-cyclopentylethyl bromide(18928-94-4)

Safety Data

• Hazardous Substances Data: 18928-94-4(Hazardous Substances Data)

Usage

General Description

β-cyclopentylethyl bromide, also known as 1-bromo-1-cyclopentylethane, is a chemical compound with the molecular formula C7H13Br. It is a colorless liquid with a slightly sweet odor and is commonly used as an alkylating agent in organic synthesis. It is also used in the pharmaceutical industry as a reagent in the production of various drugs and pharmaceutical intermediates. β-cyclopentylethyl bromide is highly reactive and can undergo various chemical reactions, including nucleophilic substitution and elimination reactions. It is important to handle this compound with care, as it is toxic and can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H13Br/c8-6-5-7-3-1-2-4-7/h7H,1-6H2

Upstream product

• 73779-38-1 2-cyclopentylethyl methanesulfonate 
• 120-92-3 cyclopentanone 
• 33240-34-5 cyclopentylmagnesium bromide 
• 2723-38-8 cyclopentylacetic acid methyl ester 
• 1540-32-5 ethyl 2-cyclopentyl-3-oxobutanoate 
• 766-02-9 2-cyclopent-2-enyl-ethanol 
• 137-43-9 Cyclopentyl bromide 
• 1123-00-8 2-cyclopentylacetic acid 
• 1903-22-6 ethyl cyclopentylideneacetate 
• 18322-54-8 ethyl cyclopentylacetate 
• 766-00-7 2-cyclopentyl-ethanol 

Downstream Products

• 6054-17-7 diethyl-(2-cyclopentyl-ethyl)-amine 
• 70895-14-6 4-(4-Chloro-phenyl)-1-(2-cyclopentyl-ethyl)-4-dimethylamino-cyclohexanol 
• 70895-14-6 4-(4-Chloro-phenyl)-1-(2-cyclopentyl-ethyl)-4-dimethylamino-cyclohexanol 
• 73779-39-2 4-(2-Cyclopentyl-ethylamino)-benzoic acid ethyl ester 
• 1025911-64-1 4-(2-Cyclopentyl-ethoxy)-3,5-dimethoxy-benzoic acid methyl ester 
• 1189798-54-6 N-(4-chlorophenyl)-N-(2-cyclopentylethyl)hydrazine 
• 1612877-82-3 1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)ethanone 
• 1612877-74-3 (E)-1-(2-(2-cyclopentylethoxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one 
• 192870-87-4 2-cyclopentyl-1-ethyltriphenylphosphonium bromide 
• 857804-05-8 (2-cyclopentyl-ethyl)-hexyl-malonic acid 
• 140-77-2 3-cyclopentylpropionic acid 
• 73779-40-5 4-(2-Cyclopentyl-ethylamino)-benzoic acid 
• 1025967-63-8 4-(2-Cyclopentyl-ethoxy)-3,5-dimethoxy-benzoic acid 
• 1027527-30-5 4-(2-Cyclopentyl-ethoxy)-3,5-dimethoxy-benzoyl chloride 

Relevant articles and documents

Structure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability

(E)-3,4-dihydroxystyryl alkyl sulfones, as new analogues of neurodegenerative agents, were designed and synthesized. The biological results demonstrated that most of the target compounds preserved antioxidant and anti-inflammatory potency in scavenging reactive free radicals, protecting neuronal cells against neurotoxins such as H2O2, 6-hydroxydopamine and inhibiting lipopolysaccharide (LPS)-induced over-production of NO. Among these compounds, 6.22 with cyclopentyl propyl exhibited prominent antioxidant activity at low concentration (2.5 μM) in H2O2 model (cell viability = 94.5%). In addition, 6.22 (IC50 = 1.6 μM) displayed better anti-inflammatory activity than that of lead compound 1 (IC50 = 13.4 μM). In view of the outstanding performance of 6.22, the apoptotic rates of H2O2-damaged PC12 cells were detected by Annexin V-FITC/PI assay. 6.22 showed higher potency in inhibition of apoptosis than 1 at low concentration (2.5 μM), consisting with the antioxidant and anti-inflammatory models. Furthermore, with the predicted CNS (+) blood-brain barrier (BBB) permeability (Pe = 6.84 × 10?6 cm s?1), low cytotoxicity and favorable physiochemical properties based on calculation, compound 6.22 can be further developed as a potential multifunctional neuroprotective agent.

Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. II. 6-Alkyl- and 6-cycloalkylalkyl derivatives

A series of 6-alkyl- or 6-(cycloalkylalkyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyr imidin-9(3H)-ones 1b-o was synthesized from the corresponding 1,3,4-thiadiazol-5-amines 3b-o and the antiallergic activities of the products were evaluated. Among the compounds 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]p yrimidin-9(3H)-one 1h, whose X-ray crystallographic stereostructure is shown, was found to be a promising new antiallergic agent, which has low toxicity and dual activity as a leukotriene D4 receptor antagonist and as an orally active mast cell stabilizer.

4-Amino-4-arylcyclohexanones and their derivatives: A novel class of analgesics. II. Modification of the carbonyl function

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