161295-05-2Relevant articles and documents
A simple synthesis of α,β-unsaturated γ-aminobutyric acid (GABA) derivatives fron enamines
Henniges,Gussetti,Militzer,Baird,De Meijere
, p. 1471 - 1475 (1994)
Bromination of enamines 3b-g at -78°C and subsequent treatment of the resulting iminium salts 4b-g with excess tert-butyl lithioacetate leads to tert-butyl 4-(N,N-dialkylamino)carboxylates 9b-g in good to very good yields. Ester cleavage of the dibenzylamino derivative 9d with trifluoroacetic acid yields the corresponding acid 10. Subsequent catalytic hydrogenation of 10 leads to the fully deprotected 4-amino-4-methylpentanoic acid (12) in high yield.
