1613022-95-9

Upstream product

• 2999-46-4 Ethyl isocyanoacetate 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1613022-46-0 1-(4-fluorophenyl)-1H-[1,2,4]triazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]amide 
• 1613021-22-9 C₂₂H₂₂FN₇O 
• 1613021-29-6 C₂₃H₂₄FN₇O 
• 1613022-45-9 1-(4-fluorophenyl)-1H-[1,2,4]triazole-3-carboxylic acid [1-(3-methyl-pyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]-amide 
• 1613021-93-4 (S)-1-(4-fluorophenyl)-N-(1-(imidazo[1,2-a]pyrazin-8-yl)pyrrolidin-3-yl)-1H-1,2,4-triazole-3-carboxamide 
• 1552231-28-3 1-(4-fluorophenyl)-1,2,4-triazole-3-carboxylic acid 
• 1613021-85-4 (S)-N-(1-([1,2,4]triazolo[4,3-a]pyrazin-8-yl)pyrrolidin-3-yl)-1-(4-fluorophenyl)-1H-1,2,4-triazole-3-carboxamide 
• 1613021-30-9 1-(4-fluorophenyl)-N-[(3S)-1-(3-isopropylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]-1,2,4-triazole-3-carboxamide trifluoroacetate 
• 1613021-23-0 N-[(3S)-1-(3-ethylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]-1-(4-fluorophenyl)-1,2,4-triazole-3-carboxamide trifluoroacetate 

Relevant academic research and scientific papers

Cycloaddition of Isocyanides with Aryl Diazonium Salts: Catalyst-Dependent Regioselective Synthesis of 1,3- and 1,5-Disubstituted 1,2,4-Triazoles

An unprecedented catalyst-dependent regioselective [3 + 2] cycloaddition of isocyanides with aryl diazonium salts is reported. 1,3-Disubstituted 1,2,4-triazoles were selectively obtained in high yield under Ag(I) catalysis, whereas 1,5-disubstituted 1,2,4-triazoles were formed by Cu(II) catalysis. These catalytic methodologies provide a controlled, modular, and facile access to 1,2,4-triazole scaffolds with high efficiency, broad substrate scope, and excellent functional group compatibility.

CXCR7 ANTAGONISTS

Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.