1613029-07-4Relevant academic research and scientific papers
Synthesis and structure activity relationship of the first class of LXR inverse agonists
Elgendy, Bahaa,Griffett, Kristine,Hegazy, Lamees,Di Fruscia, Paolo,Sample, Kirby,Schoepke, Emmalie,Kamenecka, Theodore M.,Burris, Thomas P.
, (2021/12/14)
Liver X Receptors (LXRs) are members of the nuclear receptor family, and they play significant role in lipid and cholesterol metabolism. Moreover, they are key regulators of several inflammatory pathways. Pharmacological modulation of LXRs holds great pot
SMALL MOLECULE LXR INVERSE AGONISTS
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Page/Page column 50-51; 54-55, (2014/06/23)
The invention is directed to small molecule inverse agonists of the liver X receptor, LXR. These compounds have potential use in the treatment of the following disorders: non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, insulin resistance, and metabolic syndrome. The invention is directed, in various embodiments, to small molecule inverse agonists of the liver X receptor, LXR. Administration of an effective amount of a compound of the invention, such as compound of formula (I), can be used to suppress hepatic lipogenesis, inflammation, or hepatic lipid accumulation in a mammal.
