1613042-05-9

Basic information

• Product Name: 1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one
• Synonyms: 1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one
• CAS NO: 1613042-05-9
• Molecular Weight: 263.299
• Mol File: 1613042-05-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one(1613042-05-9)
• EPA Substance Registry System: 1-(2-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one(1613042-05-9)

Safety Data

• Hazardous Substances Data: 1613042-05-9(Hazardous Substances Data)

Upstream product

• 16714-26-4 1-(2-azido-phenyl)-ethanone 
• 536-74-3 phenylacetylene 
• 2142-69-0 2-bromophenyl methyl ketone 

Relevant articles and documents

Synthesis of 2′-(1,2,3-triazoyl)-acetophenones: molecular docking and inhibition of: In vitro monoamine oxidase activity

We describe our results for the synthesis of 2′-(1,2,3-triazoyl)-acetophenones by copper catalyzed azide-alkyne cycloaddition of 2′-azidoacetophenone with alkynes. The corresponding 2′-(1,2,3-triazoyl)-acetophenones were obtained in moderate to excellent yields and according to our experiments, it was observed that ultrasound accelerates the reaction compared to conventional heating. In addition, the obtained compounds were screened by molecular docking for their possible inhibitory effect on the activity of monoamine oxidase (MAO), an enzyme responsible for the degradation of monoamine neurotransmitters. Three compounds were selected and presented an inhibitory effect on both MAO-A and B isoform activities in vitro. These new MAO inhibitors may be of interest to treat monoamine deficit related-neuropsychiatric disorders, such as depression and Parkinson's disease.